BAIT
ACD
PIP1, PTOP, TINT1, TPP1
adrenocortical dysplasia homolog (mouse)
GO Process (9)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- intracellular protein transport [IMP]
- negative regulation of telomere maintenance via telomerase [IGI, IMP]
- positive regulation of single-stranded telomeric DNA binding [IDA]
- positive regulation of telomerase activity [IDA]
- protection from non-homologous end joining at telomere [ISS]
- protein localization to chromosome, telomeric region [IMP]
- telomere assembly [IMP]
- telomere capping [IGI, NAS]
- telomere maintenance [IDA, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
EIF4B
EIF-4B, PRO1843
eukaryotic translation initiation factor 4B
GO Process (10)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- cellular protein metabolic process [TAS]
- gene expression [TAS]
- insulin receptor signaling pathway [TAS]
- mRNA metabolic process [TAS]
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [TAS]
- nuclear-transcribed mRNA poly(A) tail shortening [TAS]
- regulation of translational initiation [TAS]
- translation [TAS]
- translational initiation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
Detection of low-affinity or transient interactions can be a bottleneck in our understanding of signaling networks. To address this problem, we developed an arrayed screening strategy based on protein complementation to systematically investigate protein-protein interactions in live human cells, and performed a large-scale screen for regulators of telomeres. Maintenance of vertebrate telomeres requires the concerted action of members of the ... [more]
Mol. Cell Proteomics Feb. 01, 2011; 10(2);M110.001628 [Pubmed: 21044950]
Throughput
- High Throughput
Additional Notes
- BifC
Curated By
- BioGRID