BAIT
TONSL
IKBR, NFKBIL2
tonsoku-like, DNA repair protein
GO Process (4)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SLC25A5
2F1, AAC2, ANT2, T2, T3
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
GO Process (8)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
- adenine transport [TAS]
- energy reserve metabolic process [TAS]
- negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [IMP]
- positive regulation of cell proliferation [IMP]
- regulation of insulin secretion [TAS]
- small molecule metabolic process [TAS]
- transport [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells.
Cullin 4 (Cul4)-based ubiquitin ligases emerged as critical regulators of DNA replication and repair. Over 50 Cul4-specific adaptors (DNA damage-binding 1 (Ddb1)-Cul4-associated factors; DCAFs) have been identified and are thought to assemble functionally distinct Cul4 complexes. Using a live-cell imaging-based RNAi screen, we analysed the function of DCAFs and Cul4-linked proteins, and identified specific subsets required for progression through G1 ... [more]
EMBO J. Dec. 15, 2010; 29(24);4210-22 [Pubmed: 21113133]
Throughput
- High Throughput
Curated By
- BioGRID