LRP1
Gene Ontology Biological Process
- aorta morphogenesis [ISS]
- apoptotic cell clearance [ISS]
- beta-amyloid clearance [TAS]
- lipoprotein transport [NAS]
- negative regulation of Wnt signaling pathway [ISS]
- negative regulation of platelet-derived growth factor receptor-beta signaling pathway [ISS]
- negative regulation of smooth muscle cell migration [ISS]
- phototransduction, visible light [TAS]
- positive regulation of cholesterol efflux [ISS]
- positive regulation of lipid transport [ISS]
- regulation of actin cytoskeleton organization [ISS]
- regulation of cholesterol transport [ISS]
- regulation of phospholipase A2 activity [ISS]
- retinoid metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PID1
Gene Ontology Biological Process
- cellular response to cytokine stimulus [ISS]
- cellular response to fatty acid [ISS]
- cellular response to interleukin-6 [ISS]
- cellular response to tumor necrosis factor [ISS, NAS]
- energy reserve metabolic process [IC]
- fat cell differentiation [IDA]
- mitochondrion morphogenesis [IMP]
- negative regulation of ATP biosynthetic process [IMP]
- negative regulation of establishment of protein localization to plasma membrane [IDA]
- negative regulation of glucose import in response to insulin stimulus [IDA]
- negative regulation of insulin receptor signaling pathway [IDA]
- negative regulation of mitochondrial DNA replication [IMP]
- negative regulation of protein phosphorylation [IDA]
- positive regulation of ATP biosynthetic process [ISS]
- positive regulation of fat cell proliferation [IDA]
- positive regulation of gene expression [IMP]
- positive regulation of reactive oxygen species metabolic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of G1/S transition of mitotic cell cycle [IDA]
- regulation of mitochondrial fusion [IC]
- regulation of mitochondrial membrane potential [ISS, TAS]
- regulation of reactive oxygen species metabolic process [ISS]
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease.
The low-density lipoprotein receptor related protein 1 (LRP1) has been implicated in Alzheimer's disease (AD) but its signalling has not been fully evaluated. There is good evidence that the cytoplasmic domain of LRP1 is involved in protein-protein interactions, important in the cell biology of LRP1.We carried out three yeast two-hybrid screens to identify proteins that interact with the cytoplasmic domain ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| LRP1 PID1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID