HSP90AA1
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- axon guidance [TAS]
- chaperone-mediated protein complex assembly [IDA]
- innate immune response [TAS]
- mitochondrial transport [TAS]
- mitotic cell cycle [TAS]
- nitric oxide metabolic process [TAS]
- positive regulation of nitric oxide biosynthetic process [ISS]
- protein import into mitochondrial outer membrane [IDA]
- protein refolding [TAS]
- regulation of nitric-oxide synthase activity [TAS]
- response to unfolded protein [NAS]
- signal transduction [NAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PPARD
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- adipose tissue development [IMP]
- anagen [IMP]
- apoptotic signaling pathway [ISO]
- axon ensheathment [IMP]
- cell differentiation [IDA, IMP]
- cell proliferation [IMP]
- cell-substrate adhesion [IMP]
- cellular process [TAS]
- cellular response to hypoxia [IGI]
- embryo implantation [IDA, TAS]
- epidermis development [TAS]
- fatty acid oxidation [ISO]
- intracellular receptor signaling pathway [ISO, TAS]
- keratinocyte migration [IMP]
- keratinocyte proliferation [IMP]
- lipid metabolic process [IMP, ISO]
- mRNA transcription [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of collagen biosynthetic process [ISO]
- negative regulation of epithelial cell proliferation [IGI]
- negative regulation of inflammatory response [ISO]
- negative regulation of smooth muscle cell migration [ISO]
- negative regulation of smooth muscle cell proliferation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- phospholipid biosynthetic process [ISO]
- placenta development [IMP]
- positive regulation of catalytic activity [TAS]
- positive regulation of cell proliferation [IMP]
- positive regulation of epidermis development [ISO]
- positive regulation of insulin secretion [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of vasodilation [ISO]
- proteoglycan metabolic process [ISO]
- regulation of cell proliferation [IGI]
- regulation of fat cell differentiation [IMP]
- regulation of insulin secretion [NAS]
- regulation of transcription from RNA polymerase II promoter [ISO]
- transcription from RNA polymerase II promoter [ISO]
- vitamin A metabolic process [ISO]
- wound healing [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- NF-kappaB binding [ISO]
- drug binding [ISO]
- enzyme activator activity [TAS]
- fatty acid binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO, TAS]
- linoleic acid binding [ISO]
- lipid binding [ISO]
- prostacyclin receptor activity [TAS]
- protein heterodimerization activity [IPI, TAS]
- retinoid X receptor binding [TAS]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription coactivator activity [ISO]
- DNA binding [IDA]
- NF-kappaB binding [ISO]
- drug binding [ISO]
- enzyme activator activity [TAS]
- fatty acid binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO, TAS]
- linoleic acid binding [ISO]
- lipid binding [ISO]
- prostacyclin receptor activity [TAS]
- protein heterodimerization activity [IPI, TAS]
- retinoid X receptor binding [TAS]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription coactivator activity [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Heat shock protein-90 (Hsp90) acts as a repressor of peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARbeta activity.
The nuclear receptor (NR) peroxisome proliferator-activated receptor-alpha (PPARalpha) mediates the effects of several hypolipidemic drugs, endogenous fatty acids, and peroxisome proliferators. Despite belonging to a class of NR not known to interact with cytosolic chaperone complexes, we have recently shown that PPARalpha interacts with heat shock protein 90 (Hsp90), although the biological consequence of this association was unknown. In the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID