SIR2
Gene Ontology Biological Process
- chromatin assembly or disassembly [IDA]
- chromatin silencing at rDNA [IMP]
- chromatin silencing at silent mating-type cassette [IMP]
- chromatin silencing at telomere [IMP]
- chronological cell aging [IMP]
- negative regulation of DNA recombination [IGI]
- negative regulation of DNA replication [IMP]
- replicative cell aging [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CSM3
Gene Ontology Biological Process
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Nicotinamide induces Fob1-dependent plasmid integration into chromosome XII in Saccharomyces cerevisiae.
In the ribosomal DNA (rDNA) array of Saccharomyces cerevisiae DNA replication is arrested by the Fob1 protein in a site-specific manner that stimulates homologous recombination. The silent information regulator Sir2, which is loaded at the replication arrest sites by Fob1, suppresses this recombination event. A plasmid containing Fob1-binding sites, when propagated in a yeast strain lacking SIR2 is integrated into ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: chromosome/plasmid maintenance (APO:0000143)
Additional Notes
- suppresses plasmid integration of sir2 mutant
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SIR2 CSM3 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 521902 |
Curated By
- BioGRID