JUP
Gene Ontology Biological Process
- bundle of His cell to Purkinje myocyte communication [ISO]
- cell adhesion [IDA]
- cell migration [ISO]
- cellular response to indole-3-methanol [ISO]
- desmosome assembly [IMP, ISO]
- detection of mechanical stimulus [ISO]
- establishment of protein localization to plasma membrane [ISO]
- positive regulation of protein import into nucleus [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- protein heterooligomerization [ISO]
- regulation of cell fate specification [IBA]
- regulation of cell proliferation [ISO]
- regulation of heart rate by cardiac conduction [ISO]
- regulation of nucleic acid-templated transcription [IBA]
- single organismal cell-cell adhesion [IMP, ISO]
- skin development [IMP]
- ventricular cardiac muscle cell action potential [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Z disc [IDA]
- actin cytoskeleton [ISO]
- apicolateral plasma membrane [ISO]
- catenin complex [IBA, ISO]
- cell-cell adherens junction [IDA, ISO]
- cell-cell junction [IDA, ISO]
- cytoplasm [ISO]
- cytoplasmic side of plasma membrane [ISO]
- cytosol [IDA]
- desmosome [IDA, IMP, ISO]
- extracellular vesicular exosome [ISO]
- fascia adherens [ISO]
- focal adhesion [ISO]
- gamma-catenin-TCF7L2 complex [ISO]
- intercalated disc [ISO]
- intermediate filament [IDA]
- lateral plasma membrane [ISO]
- membrane [IDA]
- nucleus [IBA, ISO]
- plasma membrane [ISO]
- protein-DNA complex [ISO]
CTNNA1
Gene Ontology Biological Process
- apical junction assembly [IMP]
- cellular protein localization [IMP]
- cellular response to indole-3-methanol [ISO]
- epithelial cell-cell adhesion [IMP]
- establishment or maintenance of cell polarity [IMP]
- gap junction assembly [ISO]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell motility [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- negative regulation of integrin-mediated signaling pathway [IMP]
- negative regulation of neuroblast proliferation [IGI, IMP]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- positive regulation of smoothened signaling pathway [IGI]
- protein heterooligomerization [ISO]
- regulation of cell proliferation [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Mammalian formin-1 participates in adherens junctions and polymerization of linear actin cables.
During epithelial sheet formation, linear actin cables assemble at nascent adherens junctions. This process requires alpha-catenin and actin polymerization, although the underlying mechanism is poorly understood. Here, we show that formin-1 interacts with alpha-catenin, localizes to adherens junctions and nucleates unbranched actin filaments. Furthermore, disruption of the alpha-catenin-formin-1 interaction blocks assembly of radial actin cables and perturbs intercellular adhesion. A ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CTNNA1 JUP | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.933 | BioGRID | 2681567 |
Curated By
- BioGRID