PTPN11
Gene Ontology Biological Process
- DNA damage checkpoint [ISO]
- ERBB signaling pathway [ISO]
- abortive mitotic cell cycle [ISO]
- activation of MAPK activity [ISO]
- atrioventricular canal development [ISO]
- axonogenesis [ISO]
- brain development [ISO]
- dephosphorylation [ISO]
- ephrin receptor signaling pathway [ISO, ISS]
- epidermal growth factor receptor signaling pathway [ISO]
- face morphogenesis [ISO]
- genitalia development [ISO]
- glucose homeostasis [ISO]
- heart development [ISO]
- hormone metabolic process [ISO]
- hormone-mediated signaling pathway [ISO]
- inner ear development [ISO]
- integrin-mediated signaling pathway [ISO]
- lipid metabolic process [ISO]
- megakaryocyte development [ISO]
- multicellular organismal reproductive process [ISO]
- negative regulation of cell adhesion mediated by integrin [ISO]
- negative regulation of cortisol secretion [ISO]
- negative regulation of growth hormone secretion [ISO]
- negative regulation of hormone secretion [ISO]
- negative regulation of insulin secretion [ISO]
- neurotrophin TRK receptor signaling pathway [ISO]
- organ growth [ISO]
- peptidyl-tyrosine dephosphorylation [ISO, ISS]
- platelet formation [ISO]
- platelet-derived growth factor receptor signaling pathway [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of glucose import in response to insulin stimulus [ISO]
- positive regulation of hormone secretion [ISO]
- positive regulation of mitotic cell cycle [ISO]
- positive regulation of signal transduction [ISO]
- protein dephosphorylation [IDA]
- regulation of cell adhesion mediated by integrin [ISO, ISS]
- regulation of multicellular organism growth [ISO]
- regulation of protein export from nucleus [ISO]
- triglyceride metabolic process [ISO]
Gene Ontology Molecular Function- D1 dopamine receptor binding [IPI]
- SH3/SH2 adaptor activity [ISO]
- insulin receptor binding [IDA, ISO]
- insulin receptor substrate binding [IPI]
- non-membrane spanning protein tyrosine phosphatase activity [ISO, ISS]
- peptide hormone receptor binding [ISO]
- phospholipase binding [IDA]
- phosphoprotein phosphatase activity [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein tyrosine phosphatase activity [IDA, ISO]
- receptor tyrosine kinase binding [ISO]
- D1 dopamine receptor binding [IPI]
- SH3/SH2 adaptor activity [ISO]
- insulin receptor binding [IDA, ISO]
- insulin receptor substrate binding [IPI]
- non-membrane spanning protein tyrosine phosphatase activity [ISO, ISS]
- peptide hormone receptor binding [ISO]
- phospholipase binding [IDA]
- phosphoprotein phosphatase activity [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein tyrosine phosphatase activity [IDA, ISO]
- receptor tyrosine kinase binding [ISO]
BCAR1
Gene Ontology Biological Process
- B cell receptor signaling pathway [ISO, ISS]
- G-protein coupled receptor signaling pathway [ISO, ISS]
- actin cytoskeleton organization [IMP]
- actin filament organization [ISO, ISS]
- antigen receptor-mediated signaling pathway [ISO, ISS]
- cell chemotaxis [ISO]
- cell migration [IMP, ISO, ISS]
- cellular response to hepatocyte growth factor stimulus [ISO]
- epidermal growth factor receptor signaling pathway [IDA]
- hepatocyte growth factor receptor signaling pathway [ISO]
- insulin receptor signaling pathway [IDA]
- integrin-mediated signaling pathway [ISO, ISS]
- neurotrophin TRK receptor signaling pathway [IDA]
- platelet-derived growth factor receptor signaling pathway [ISO, ISS]
- positive regulation of cell migration [ISO, ISS]
- positive regulation of endothelial cell migration [ISO]
- vascular endothelial growth factor receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Opposite regulation of tyrosine-phosphorylation of p130(Cas) by insulin and insulin-like growth factor I.
To investigate the difference in signaling between insulin and insulin-like growth factor I (IGF-I), we studied the effects of these hormones on the phosphorylation state of Crk-associated substrate (Cas) in cells expressing human insulin receptor (HIRc). In the basal state, Cas was heavily tyrosine-phosphorylated, and insulin dephosphorylated Cas in a time- and dose-dependent manner. On the other hand, IGF-I phosphorylated ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 6.
Curated By
- BioGRID