BAIT
FAS
ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6, RP11-399O19.7
Fas cell surface death receptor
GO Process (12)
GO Function (5)
GO Component (9)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [TAS]
- apoptotic process [IDA, TAS]
- apoptotic signaling pathway [TAS]
- cellular response to hyperoxia [IMP]
- cellular response to mechanical stimulus [IEP]
- extrinsic apoptotic signaling pathway [IMP]
- necroptotic signaling pathway [IMP]
- positive regulation of apoptotic process [IDA, IMP]
- protein complex assembly [TAS]
- regulation of apoptotic process [NAS]
- regulation of extrinsic apoptotic signaling pathway in absence of ligand [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TRAF3
CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1
TNF receptor-associated factor 3
GO Process (14)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- innate immune response [TAS]
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of type I interferon production [TAS]
- regulation of cytokine production [ISS]
- regulation of defense response to virus [ISS]
- regulation of interferon-beta production [ISS]
- regulation of proteolysis [IMP]
- signal transduction [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [ISS, TAS]
- tumor necrosis factor-mediated signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family.
The cytoplasmic C-terminus of Epstein-Barr virus (EBV) latent infection membrane protein 1 (LMP1) is essential for B lymphocyte growth transformation and is now shown to interact with a novel human protein (LMP1-associated protein 1 [LAP1]). LAP1 is homologous to a murine protein, tumor necrosis factor receptor-associated factor 2 (TRAF2), implicated in growth signaling from the p80 TNFR. A second novel ... [more]
Cell Feb. 10, 1995; 80(3);389-99 [Pubmed: 7859281]
Throughput
- Low Throughput
Curated By
- BioGRID