LNX1
Gene Ontology Molecular Function
SNW1
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- cellular response to retinoic acid [IDA]
- gene expression [TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP]
- mRNA splicing, via spliceosome [IC, IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation by host of viral transcription [IDA, IMP]
- positive regulation of histone H3-K4 methylation [IMP]
- positive regulation of mRNA splicing, via spliceosome [IMP]
- positive regulation of neurogenesis [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transforming growth factor beta receptor signaling pathway [IDA]
- positive regulation of vitamin D receptor signaling pathway [IDA]
- regulation of retinoic acid receptor signaling pathway [IDA]
- regulation of transcription from RNA polymerase II promoter [TAS]
- regulation of vitamin D receptor signaling pathway [IDA]
- retinoic acid receptor signaling pathway [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Characterization of human LNX, a novel ligand of Numb protein X that is downregulated in human gliomas.
Gliomas are major tumors of the central nervous system with a wide spectrum of different tumor types. Ligand of Numb protein X (LNX) is PDZ domain containing protein that interacts with cell fate determinant Numb. cDNA microarray analysis was used to determine the expression of 13,939 genes in a set of 18 gliomas. It showed that human LNX was downregulated ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID