PRKAA2
Gene Ontology Biological Process
- carnitine shuttle [TAS]
- cell cycle arrest [TAS]
- cellular lipid metabolic process [TAS]
- cellular response to glucose starvation [ISS]
- cellular response to nutrient levels [ISS]
- energy reserve metabolic process [TAS]
- fatty acid homeostasis [ISS]
- glucose homeostasis [ISS]
- insulin receptor signaling pathway [TAS]
- lipid biosynthetic process [ISS]
- membrane organization [TAS]
- negative regulation of TOR signaling [ISS]
- negative regulation of apoptotic process [ISS]
- positive regulation of autophagy [ISS]
- positive regulation of glycolytic process [ISS]
- protein phosphorylation [TAS]
- regulation of circadian rhythm [ISS]
- regulation of energy homeostasis [ISS]
- regulation of fatty acid biosynthetic process [TAS]
- response to stress [ISS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytosol [TAS]
- nucleoplasm [TAS]
RPTOR
Gene Ontology Biological Process
- TOR signaling [IDA]
- cell cycle arrest [TAS]
- cell growth [IMP]
- cellular response to amino acid stimulus [IMP]
- cellular response to nutrient levels [IMP]
- insulin receptor signaling pathway [TAS]
- positive regulation of TOR signaling [IDA]
- positive regulation of protein serine/threonine kinase activity [IDA]
- positive regulation of transcription from RNA polymerase III promoter [IMP]
- regulation of cell size [IMP]
Gene Ontology Molecular Function- 14-3-3 protein binding [IDA]
- RNA polymerase III type 1 promoter DNA binding [IDA]
- RNA polymerase III type 2 promoter DNA binding [IDA]
- RNA polymerase III type 3 promoter DNA binding [IDA]
- TFIIIC-class transcription factor binding [IDA]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase binding [IPI]
- 14-3-3 protein binding [IDA]
- RNA polymerase III type 1 promoter DNA binding [IDA]
- RNA polymerase III type 2 promoter DNA binding [IDA]
- RNA polymerase III type 3 promoter DNA binding [IDA]
- TFIIIC-class transcription factor binding [IDA]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase binding [IPI]
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
AMPK phosphorylation of raptor mediates a metabolic checkpoint.
AMPK is a highly conserved sensor of cellular energy status that is activated under conditions of low intracellular ATP. AMPK responds to energy stress by suppressing cell growth and biosynthetic processes, in part through its inhibition of the rapamycin-sensitive mTOR (mTORC1) pathway. AMPK phosphorylation of the TSC2 tumor suppressor contributes to suppression of mTORC1; however, TSC2-deficient cells remain responsive to ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID