TNFRSF11A
Gene Ontology Biological Process
- TNFSF11-mediated signaling pathway [IMP]
- adaptive immune response [IMP]
- cell-cell signaling [TAS]
- circadian temperature homeostasis [ISS]
- monocyte chemotaxis [NAS]
- osteoclast differentiation [IMP]
- positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling [IMP]
- positive regulation of JUN kinase activity [IMP]
- positive regulation of NF-kappaB transcription factor activity [IDA, IMP]
- positive regulation of cell proliferation [TAS]
- positive regulation of fever generation by positive regulation of prostaglandin secretion [ISS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA, ISS]
- response to cytokine [IMP]
- response to interleukin-1 [ISS]
- response to lipopolysaccharide [ISS]
- response to tumor necrosis factor [ISS]
- signal transduction [TAS]
- tumor necrosis factor-mediated signaling pathway [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TRAF3
Gene Ontology Biological Process
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- innate immune response [TAS]
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of type I interferon production [TAS]
- regulation of cytokine production [ISS]
- regulation of defense response to virus [ISS]
- regulation of interferon-beta production [ISS]
- regulation of proteolysis [IMP]
- signal transduction [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [ISS, TAS]
- tumor necrosis factor-mediated signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor.
Tumor necrosis factor (TNF)-related activation-induced cytokine (TRANCE), a member of the TNF family expressed on activated T-cells, bone marrow stromal cells, and osteoblasts, regulates the function of dendritic cells (DC) and osteoclasts. The TRANCE receptor (TRANCE-R), recently identified as receptor activator of NF-kappabeta (RANK), activates NF-kappaB, a transcription factor critical in the differentiation and activation of those cells. In this ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TNFRSF11A TRAF3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| TNFRSF11A TRAF3 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| TNFRSF11A TRAF3 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID