BAIT
RABGEF1
Rab5ef, Rabex5, Rin2
RAB guanine nucleotide exchange factor (GEF) 1
GO Process (13)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- negative regulation of Kit signaling pathway [IMP]
- negative regulation of Ras protein signal transduction [IMP]
- negative regulation of inflammatory response [IMP]
- negative regulation of interleukin-6 secretion [IMP]
- negative regulation of leukocyte migration [IMP]
- negative regulation of mast cell activation [IMP]
- negative regulation of mast cell degranulation [IMP]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of receptor-mediated endocytosis [IMP]
- positive regulation of Rab GTPase activity [ISO]
- protein targeting to membrane [ISO]
- protein ubiquitination [IDA]
- regulation of Fc receptor mediated stimulatory signaling pathway [IDA, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
RABEP1
Rab5ep, rabaptin-5, rabaptin-5alpha, DN-279H6.1
rabaptin, RAB GTPase binding effector protein 1
GO Process (0)
GO Function (2)
GO Component (3)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Two distinct effectors of the small GTPase Rab5 cooperate in endocytic membrane fusion.
Using the yeast two-hybrid system, we have identified a novel 62 kDa coiled-coil protein that specifically interacts with the GTP-bound form of Rab5, a small GTPase that regulates membrane traffic in the early endocytic pathway. This protein shares 42% sequence identity with Rabaptin-5, a previously identified effector of Rab5, and we therefore named it Rabaptin-5beta. Like Rabaptin-5, Rabaptin-5beta displays heptad ... [more]
EMBO J. Apr. 01, 1998; 17(7);1930-40 [Pubmed: 9524116]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RABGEF1 RABEP1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID