TNFRSF1B
Gene Ontology Biological Process
- RNA destabilization [IMP]
- cell proliferation [TAS]
- cell surface receptor signaling pathway [IMP]
- cellular response to lipopolysaccharide [ISO]
- extrinsic apoptotic signaling pathway [IMP]
- immune response [ISO]
- inflammatory response [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- negative regulation of inflammatory response [IMP]
- positive regulation of membrane protein ectodomain proteolysis [ISO]
- programmed cell death [IPI]
- tumor necrosis factor-mediated signaling pathway [IPI, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TRAF1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins.
The 75 kDa tumor necrosis factor receptor (TNFR2) transduces extracellular signals via receptor-associated cytoplasmic proteins. Two of these signal transducers, TRAF1 and TRAF2, were isolated and characterized previously. We report here the biochemical purification and subsequent molecular cloning of two novel TNFR2-associated proteins, designated c-IAP1 and c-IAP2, that are closely related mammalian members of the inhibitor of apoptosis protein (IAP) ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TNFRSF1B TRAF1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID