BAIT
TNFRSF12A
AI255180, C87282, Fn14, HPIP, TWEAK-R, TweakR
tumor necrosis factor receptor superfamily, member 12a
GO Process (8)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- cell adhesion [IDA]
- extrinsic apoptotic signaling pathway [IDA]
- positive regulation of apoptotic process [ISO]
- positive regulation of axon extension [IDA]
- positive regulation of extrinsic apoptotic signaling pathway [ISO]
- regulation of angiogenesis [IDA]
- regulation of wound healing [ISO]
- substrate-dependent cell migration, cell attachment to substrate [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
TRAF3
CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1
TNF receptor-associated factor 3
GO Process (14)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- innate immune response [TAS]
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of type I interferon production [TAS]
- regulation of cytokine production [ISS]
- regulation of defense response to virus [ISS]
- regulation of interferon-beta production [ISS]
- regulation of proteolysis [IMP]
- signal transduction [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [ISS, TAS]
- tumor necrosis factor-mediated signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation.
Fn14 is a growth-factor-inducible immediate-early-response gene encoding a 102-amino-acid type I transmembrane protein. The human Fn14 protein was recently identified as a cell-surface receptor for the tumour necrosis factor (TNF) superfamily member named TWEAK (TNF-like weak inducer of apoptosis). In the present paper, we report that the human TWEAK extracellular domain can also bind the murine Fn14 protein. Furthermore, site-specific ... [more]
Biochem. J. Apr. 15, 2003; 371(0);395-403 [Pubmed: 12529173]
Throughput
- Low Throughput
Curated By
- BioGRID