BAIT

SLX1A

GIYD1
SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)
Fanconi Anemia Project
Homo sapiens
PREY

EME1

MMS4L, SLX2A
essential meiotic structure-specific endonuclease 1
Fanconi Anemia Project
GO Process (1)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair.

Munoz IM, Hain K, Declais AC, Gardiner M, Toh GW, Sanchez-Pulido L, Heuckmann JM, Toth R, Macartney T, Eppink B, Kanaar R, Ponting CP, Lilley DM, Rouse J

Budding yeast Slx4 interacts with the structure-specific endonuclease Slx1 to ensure completion of ribosomal DNA replication. Slx4 also interacts with the Rad1-Rad10 endonuclease to control cleavage of 3' flaps during repair of double-strand breaks (DSBs). Here we describe the identification of human SLX4, a scaffold for DNA repair nucleases XPF-ERCC1, MUS81-EME1, and SLX1. SLX4 immunoprecipitates show SLX1-dependent nuclease activity toward ... [more]

Mol. Cell Jul. 10, 2009; 35(1);116-27 [Pubmed: 19595721]

Throughput

  • Low Throughput

Curated By

  • BioGRID