IL1RAP
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TICAM2
Gene Ontology Biological Process
- I-kappaB kinase/NF-kappaB signaling [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRAM-dependent toll-like receptor 4 signaling pathway [IDA, IMP]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- cellular response to lipopolysaccharide [IDA, IMP]
- innate immune response [TAS]
- negative regulation of chemokine (C-C motif) ligand 5 production [IMP]
- negative regulation of toll-like receptor 4 signaling pathway [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of chemokine (C-C motif) ligand 5 production [IMP]
- positive regulation of interleukin-18-mediated signaling pathway [IMP]
- positive regulation of toll-like receptor 4 signaling pathway [IDA, IMP]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling.
The Toll/interleukin-1 receptor (TIR) family members play important roles in host defense. These receptors signal through TIR domain-containing adapter proteins. In this report, we identified a novel TIR domain-containing adapter protein designated as TIRP. Co-immunoprecipitation experiments suggest that TIRP is associated with IL-1 receptors. TIRP also interacts with kinase-inactive mutants of IRAK and IRAK-4, IRAK-2, IRAK-M, and TRAF6. Overexpression of ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID