BAIT
UBQLN4
A1U, A1Up, C1orf6, CIP75, UBIN, RP11-336K24.8
ubiquilin 4
GO Process (1)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CCL21
6Ckine, CKb9, ECL, SCYA21, SLC, TCA4, RP11-195F19.22-001
chemokine (C-C motif) ligand 21
GO Process (37)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- T cell costimulation [ISS]
- activation of Rho GTPase activity [IDA]
- cell chemotaxis [IDA]
- cell maturation [ISS]
- cell-cell signaling [TAS]
- dendritic cell chemotaxis [IDA]
- dendritic cell dendrite assembly [ISS]
- establishment of T cell polarity [IDA]
- immunological synapse formation [ISS]
- inflammatory response [NAS]
- mesangial cell-matrix adhesion [IDA]
- negative regulation of dendritic cell dendrite assembly [ISS]
- negative regulation of leukocyte apoptotic process [IDA]
- negative regulation of leukocyte tethering or rolling [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of JNK cascade [IDA]
- positive regulation of T cell migration [IDA]
- positive regulation of actin filament polymerization [IDA]
- positive regulation of cell adhesion mediated by integrin [IDA]
- positive regulation of cell motility [IDA]
- positive regulation of cell-matrix adhesion [IDA]
- positive regulation of chemotaxis [ISS]
- positive regulation of dendritic cell antigen processing and presentation [ISS]
- positive regulation of filopodium assembly [IDA]
- positive regulation of glycoprotein biosynthetic process [ISS]
- positive regulation of myeloid dendritic cell chemotaxis [IDA]
- positive regulation of neutrophil chemotaxis [IDA]
- positive regulation of phosphatidylinositol 3-kinase activity [IDA]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of protein kinase activity [IDA]
- positive regulation of pseudopodium assembly [IDA]
- positive regulation of receptor-mediated endocytosis [ISS]
- release of sequestered calcium ion into cytosol [IDA]
- response to prostaglandin E [IDA]
- ruffle organization [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
Many human inherited neurodegenerative disorders are characterized by loss of balance due to cerebellar Purkinje cell (PC) degeneration. Although the disease-causing mutations have been identified for a number of these disorders, the normal functions of the proteins involved remain, in many cases, unknown. To gain insight into the function of proteins involved in PC degeneration, we developed an interaction network ... [more]
Cell May. 19, 2006; 125(4);801-14 [Pubmed: 16713569]
Throughput
- High Throughput
Curated By
- BioGRID