BAIT
HSPA4
APG-2, HEL-S-5a, HS24/P52, HSPH2, RY, hsp70, hsp70RY
heat shock 70kDa protein 4
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DDIT4
Dig2, REDD-1, REDD1, RP11-442H21.1
DNA-damage-inducible transcript 4
GO Process (12)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
- brain development [ISS]
- cell proliferation [ISS]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [ISS]
- negative regulation of TOR signaling [IMP]
- negative regulation of intracellular signal transduction [ISS]
- negative regulation of peptidyl-serine phosphorylation [ISS]
- negative regulation of peptidyl-threonine phosphorylation [ISS]
- neuron differentiation [ISS]
- neuron migration [ISS]
- neurotrophin TRK receptor signaling pathway [ISS]
- positive regulation of neuron death [ISS]
- response to hypoxia [IDA]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
Many human inherited neurodegenerative disorders are characterized by loss of balance due to cerebellar Purkinje cell (PC) degeneration. Although the disease-causing mutations have been identified for a number of these disorders, the normal functions of the proteins involved remain, in many cases, unknown. To gain insight into the function of proteins involved in PC degeneration, we developed an interaction network ... [more]
Cell May. 19, 2006; 125(4);801-14 [Pubmed: 16713569]
Throughput
- High Throughput
Curated By
- BioGRID