BAIT
AVPR2
ADHR, DI1, DIR, DIR3, NDI, V2R
arginine vasopressin receptor 2
GO Process (12)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- activation of adenylate cyclase activity [TAS]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [TAS]
- cellular response to hormone stimulus [IBA]
- excretion [TAS]
- hemostasis [TAS]
- positive regulation of gene expression [ISS]
- positive regulation of protein ubiquitination [NAS]
- positive regulation of vasoconstriction [IBA]
- regulation of systemic arterial blood pressure by vasopressin [IBA]
- response to peptide [IBA]
- transmembrane transport [TAS]
- water transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GNAS
AHO, C20orf45, GNAS1, GPSA, GSA, GSP, NESP, PHP1A, PHP1B, PHP1C, POH, RP4-543J19.4
GNAS complex locus
GO Process (29)
GO Function (11)
GO Component (10)
Gene Ontology Biological Process
- activation of adenylate cyclase activity [TAS]
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [IDA, IMP]
- adenylate cyclase-activating adrenergic receptor signaling pathway [IDA]
- adenylate cyclase-activating dopamine receptor signaling pathway [IBA, ISS]
- blood coagulation [TAS]
- bone development [IDA, IMP]
- cAMP biosynthetic process [TAS]
- cellular response to catecholamine stimulus [ISS]
- cellular response to glucagon stimulus [TAS]
- cellular response to prostaglandin E stimulus [ISS]
- cognition [IDA, IMP]
- developmental growth [IDA, IMP]
- energy reserve metabolic process [TAS]
- female pregnancy [NAS]
- hair follicle placode formation [IDA, IMP]
- intracellular transport [NAS]
- negative regulation of multicellular organism growth [ISS]
- platelet aggregation [IDA, IMP]
- positive regulation of Ras GTPase activity [IDA]
- positive regulation of cAMP biosynthetic process [IDA]
- positive regulation of cAMP-mediated signaling [IDA]
- protein secretion [NAS]
- regulation of insulin secretion [TAS]
- response to parathyroid hormone [IMP]
- sensory perception of chemical stimulus [IBA]
- sensory perception of smell [TAS]
- small molecule metabolic process [TAS]
- transmembrane transport [TAS]
- water transport [TAS]
Gene Ontology Molecular Function- D1 dopamine receptor binding [IBA]
- G-protein beta/gamma-subunit complex binding [IBA]
- GTPase activity [IBA, TAS]
- adenylate cyclase activity [TAS]
- beta-2 adrenergic receptor binding [IBA]
- corticotropin-releasing hormone receptor 1 binding [IBA]
- insulin-like growth factor receptor binding [IBA]
- ionotropic glutamate receptor binding [IBA]
- mu-type opioid receptor binding [IBA]
- protein binding [IPI]
- signal transducer activity [IBA, IDA]
- D1 dopamine receptor binding [IBA]
- G-protein beta/gamma-subunit complex binding [IBA]
- GTPase activity [IBA, TAS]
- adenylate cyclase activity [TAS]
- beta-2 adrenergic receptor binding [IBA]
- corticotropin-releasing hormone receptor 1 binding [IBA]
- insulin-like growth factor receptor binding [IBA]
- ionotropic glutamate receptor binding [IBA]
- mu-type opioid receptor binding [IBA]
- protein binding [IPI]
- signal transducer activity [IBA, IDA]
Gene Ontology Cellular Component
Homo sapiens
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
Real-time monitoring of receptor and G-protein interactions in living cells.
G protein-coupled receptors (GPCRs) represent the largest family of proteins involved in signal transduction. Here we present a bioluminescence resonance energy transfer (BRET) assay that directly monitors in real time the early interactions between human GPCRs and their cognate G-protein subunits in living human cells. In addition to detecting basal precoupling of the receptors to Galpha-, Gbeta- and Ggamma-subunits, BRET ... [more]
Nat. Methods Mar. 01, 2005; 2(3);177-84 [Pubmed: 15782186]
Throughput
- Low Throughput
Additional Notes
- interaction detected by BRET
Curated By
- BioGRID