BAIT
TBXA2R
BDPLT13, TXA2-R
thromboxane A2 receptor
GO Process (5)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GNAS
AHO, C20orf45, GNAS1, GPSA, GSA, GSP, NESP, PHP1A, PHP1B, PHP1C, POH, RP4-543J19.4
GNAS complex locus
GO Process (29)
GO Function (11)
GO Component (10)
Gene Ontology Biological Process
- activation of adenylate cyclase activity [TAS]
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [IDA, IMP]
- adenylate cyclase-activating adrenergic receptor signaling pathway [IDA]
- adenylate cyclase-activating dopamine receptor signaling pathway [IBA, ISS]
- blood coagulation [TAS]
- bone development [IDA, IMP]
- cAMP biosynthetic process [TAS]
- cellular response to catecholamine stimulus [ISS]
- cellular response to glucagon stimulus [TAS]
- cellular response to prostaglandin E stimulus [ISS]
- cognition [IDA, IMP]
- developmental growth [IDA, IMP]
- energy reserve metabolic process [TAS]
- female pregnancy [NAS]
- hair follicle placode formation [IDA, IMP]
- intracellular transport [NAS]
- negative regulation of multicellular organism growth [ISS]
- platelet aggregation [IDA, IMP]
- positive regulation of Ras GTPase activity [IDA]
- positive regulation of cAMP biosynthetic process [IDA]
- positive regulation of cAMP-mediated signaling [IDA]
- protein secretion [NAS]
- regulation of insulin secretion [TAS]
- response to parathyroid hormone [IMP]
- sensory perception of chemical stimulus [IBA]
- sensory perception of smell [TAS]
- small molecule metabolic process [TAS]
- transmembrane transport [TAS]
- water transport [TAS]
Gene Ontology Molecular Function- D1 dopamine receptor binding [IBA]
- G-protein beta/gamma-subunit complex binding [IBA]
- GTPase activity [IBA, TAS]
- adenylate cyclase activity [TAS]
- beta-2 adrenergic receptor binding [IBA]
- corticotropin-releasing hormone receptor 1 binding [IBA]
- insulin-like growth factor receptor binding [IBA]
- ionotropic glutamate receptor binding [IBA]
- mu-type opioid receptor binding [IBA]
- protein binding [IPI]
- signal transducer activity [IBA, IDA]
- D1 dopamine receptor binding [IBA]
- G-protein beta/gamma-subunit complex binding [IBA]
- GTPase activity [IBA, TAS]
- adenylate cyclase activity [TAS]
- beta-2 adrenergic receptor binding [IBA]
- corticotropin-releasing hormone receptor 1 binding [IBA]
- insulin-like growth factor receptor binding [IBA]
- ionotropic glutamate receptor binding [IBA]
- mu-type opioid receptor binding [IBA]
- protein binding [IPI]
- signal transducer activity [IBA, IDA]
Gene Ontology Cellular Component
Homo sapiens
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
Real-time monitoring of receptor and G-protein interactions in living cells.
G protein-coupled receptors (GPCRs) represent the largest family of proteins involved in signal transduction. Here we present a bioluminescence resonance energy transfer (BRET) assay that directly monitors in real time the early interactions between human GPCRs and their cognate G-protein subunits in living human cells. In addition to detecting basal precoupling of the receptors to Galpha-, Gbeta- and Ggamma-subunits, BRET ... [more]
Nat. Methods Mar. 01, 2005; 2(3);177-84 [Pubmed: 15782186]
Throughput
- Low Throughput
Additional Notes
- Isoforms (Uniprot IDs): P21731-3 interacts with Q5FWY2
- Thromboxane receptor alpha interacted with G protein subunits
- interaction detected by BRET
Curated By
- BioGRID