BAIT
PLK3
CNK, FNK, PRK, RP11-269F19.6
polo-like kinase 3
GO Process (19)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- G2/M transition of mitotic cell cycle [TAS]
- Golgi disassembly [IDA]
- apoptotic process [TAS]
- cellular response to DNA damage stimulus [IDA, IMP]
- cytoplasmic microtubule organization [IMP]
- endomitotic cell cycle [TAS]
- mitotic G1/S transition checkpoint [ISS]
- mitotic cell cycle checkpoint [TAS]
- negative regulation of apoptotic process [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of intracellular protein transport [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia [IDA]
- protein kinase B signaling [ISS]
- regulation of cell division [IDA]
- regulation of cytokinesis [IMP, TAS]
- response to osmotic stress [IDA]
- response to radiation [IDA]
- response to reactive oxygen species [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
AURKA
AIK, ARK1, AURA, AURORA2, BTAK, PPP1R47, STK15, STK6, STK7, RP5-1167H4.6
aurora kinase A
GO Process (13)
GO Function (6)
GO Component (12)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- mitotic cell cycle [TAS]
- mitotic nuclear division [TAS]
- mitotic spindle organization [IBA]
- negative regulation of protein binding [IDA]
- positive regulation of mitosis [TAS]
- protein autophosphorylation [TAS]
- protein phosphorylation [IDA]
- regulation of centrosome cycle [TAS]
- regulation of cytokinesis [IBA]
- regulation of protein stability [IMP]
- spindle stabilization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- centrosome [IDA, TAS]
- chromosome passenger complex [IBA]
- condensed nuclear chromosome, centromeric region [IBA]
- cytosol [TAS]
- microtubule cytoskeleton [IDA]
- midbody [TAS]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- spindle [TAS]
- spindle microtubule [IDA]
- spindle midzone [IBA]
- spindle pole centrosome [IDA]
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Physical and functional interactions between mitotic kinases during polyploidization and megakaryocytic differentiation.
Human Polo-like kinase 3 (Plk3), a protein serine/threonine kinase, is involved in the regulation of cell cycle progression at multiple stages. Our previous studies revealed that Plk3 is closely associated with centrosomes and plays an important role in the regulation of microtubule dynamics. Here we describe the physical interaction of Plk3 with Aurora A and BubR1 kinases, and the significance ... [more]
Cell Cycle Jul. 01, 2004; 3(7);946-51 [Pubmed: 15190214]
Throughput
- Low Throughput
Curated By
- BioGRID