PDE4B
Gene Ontology Biological Process
- T cell receptor signaling pathway [IMP]
- cAMP catabolic process [IDA, IGI]
- cellular response to drug [ISS]
- cellular response to epinephrine stimulus [ISS]
- cellular response to lipopolysaccharide [ISS]
- leukocyte migration [ISS]
- negative regulation of relaxation of cardiac muscle [ISS]
- neutrophil chemotaxis [ISS]
- neutrophil homeostasis [ISS]
- positive regulation of interferon-gamma production [IMP]
- positive regulation of interleukin-2 production [IMP]
- regulation of cardiac muscle cell contraction [ISS]
- regulation of high voltage-gated calcium channel activity [ISS]
Gene Ontology Molecular Function
PAFAH1B1
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- acrosome assembly [ISS]
- actin cytoskeleton organization [ISS]
- adult locomotory behavior [IMP]
- brain morphogenesis [IMP]
- cerebral cortex development [IMP]
- corpus callosum morphogenesis [IMP]
- establishment of mitotic spindle orientation [IMP]
- hippocampus development [ISS]
- layer formation in cerebral cortex [ISS]
- learning or memory [ISS]
- microtubule cytoskeleton organization [ISS]
- microtubule organizing center organization [IMP]
- microtubule-based process [IDA]
- mitotic cell cycle [TAS]
- neuroblast proliferation [ISS]
- neuromuscular process controlling balance [IMP]
- neuron migration [IMP, ISS]
- platelet activating factor metabolic process [ISS]
- regulation of Rho GTPase activity [ISS]
- retrograde axon cargo transport [ISS]
- synaptic transmission [ISS]
- transmission of nerve impulse [ISS]
- vesicle transport along microtubule [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function.
LIS1, a WD40 repeat scaffold protein, interacts with components of the cytoplasmic dynein motor complex to regulate dynein-dependent cell motility. Here, we reveal that cAMP-specific phosphodiesterases (PDE4s) directly bind PAFAH1B1 (also known as LIS1). Dissociation of LIS1-dynein complexes is coupled with loss of dynein function, as determined in assays of both microtubule transport and directed cell migration in wounded monolayers. ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PAFAH1B1 PDE4B | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID