EP300
Gene Ontology Biological Process
- N-terminal peptidyl-lysine acetylation [ISO, ISS]
- apoptotic process [ISO, ISS]
- cartilage development [NAS]
- circadian rhythm [IDA]
- heart development [IMP]
- histone H2B acetylation [ISO]
- histone H3 acetylation [ISO]
- histone H4 acetylation [ISO, ISS]
- histone acetylation [ISO]
- internal peptidyl-lysine acetylation [ISO]
- internal protein amino acid acetylation [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [ISO]
- lung development [IMP]
- negative regulation of cell death [ISO]
- negative regulation of cellular metabolic process [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of miRNA metabolic process [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- organ morphogenesis [IMP]
- positive regulation by host of viral transcription [ISO]
- positive regulation of DNA binding [ISO]
- positive regulation of axon extension [ISO]
- positive regulation of cell death [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cell size [ISO]
- positive regulation of cellular metabolic process [ISO]
- positive regulation of collagen biosynthetic process [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of glycoprotein biosynthetic process [ISO]
- positive regulation of histone acetylation [ISO]
- positive regulation of muscle atrophy [ISO]
- positive regulation of protein acetylation [ISO]
- positive regulation of protein binding [IDA]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein secretion [ISO]
- positive regulation of proteolysis [ISO]
- positive regulation of sarcomere organization [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA, ISO, ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of translation [ISO]
- protein kinase B signaling [ISO]
- protein-DNA complex assembly [ISO]
- regulation of androgen receptor signaling pathway [ISO]
- regulation of angiotensin metabolic process [ISO]
- regulation of nucleic acid-templated transcription [IMP]
- regulation of transcription, DNA-templated [IDA, ISO, ISS]
- regulation of tubulin deacetylation [ISO]
- response to calcium ion [ISO]
- response to dexamethasone [ISO]
- response to drug [ISO]
- response to estrogen [ISO]
- response to glucose [ISO]
- response to hypoxia [ISO, ISS]
- skeletal muscle tissue development [IMP]
- somitogenesis [IGI]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA, ISO, ISS]
- NF-kappaB binding [ISO]
- RNA polymerase II activating transcription factor binding [IPI, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II transcription factor binding [IPI]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SMAD binding [ISO]
- acetyltransferase activity [IDA, ISO, ISS]
- activating transcription factor binding [ISO]
- androgen receptor binding [ISO]
- antigen binding [ISO]
- bHLH transcription factor binding [ISO]
- beta-catenin binding [ISO]
- chromatin DNA binding [IDA, ISO]
- chromatin binding [ISO]
- core promoter binding [ISO]
- core promoter proximal region DNA binding [ISO]
- glucocorticoid receptor binding [ISO]
- histone acetyltransferase activity [ISO, ISS]
- lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [ISO]
- mitogen-activated protein kinase binding [ISO]
- nuclear hormone receptor binding [ISO]
- p53 binding [IPI, ISO]
- peroxisome proliferator activated receptor binding [ISO]
- pre-mRNA intronic binding [IDA]
- protein C-terminus binding [ISO]
- protein antigen binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription coactivator activity [IMP, ISO, ISS]
- transcription factor binding [IPI, ISO]
- transferase activity, transferring acyl groups [ISO]
- DNA binding [IDA, ISO, ISS]
- NF-kappaB binding [ISO]
- RNA polymerase II activating transcription factor binding [IPI, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II transcription factor binding [IPI]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SMAD binding [ISO]
- acetyltransferase activity [IDA, ISO, ISS]
- activating transcription factor binding [ISO]
- androgen receptor binding [ISO]
- antigen binding [ISO]
- bHLH transcription factor binding [ISO]
- beta-catenin binding [ISO]
- chromatin DNA binding [IDA, ISO]
- chromatin binding [ISO]
- core promoter binding [ISO]
- core promoter proximal region DNA binding [ISO]
- glucocorticoid receptor binding [ISO]
- histone acetyltransferase activity [ISO, ISS]
- lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [ISO]
- mitogen-activated protein kinase binding [ISO]
- nuclear hormone receptor binding [ISO]
- p53 binding [IPI, ISO]
- peroxisome proliferator activated receptor binding [ISO]
- pre-mRNA intronic binding [IDA]
- protein C-terminus binding [ISO]
- protein antigen binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription coactivator activity [IMP, ISO, ISS]
- transcription factor binding [IPI, ISO]
- transferase activity, transferring acyl groups [ISO]
Gene Ontology Cellular Component
TCF12
Gene Ontology Biological Process
Gene Ontology Molecular Function- DNA binding [IDA]
- E-box binding [IDA]
- HMG box domain binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- SMAD binding [ISO]
- bHLH transcription factor binding [ISO]
- cAMP response element binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- DNA binding [IDA]
- E-box binding [IDA]
- HMG box domain binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- SMAD binding [ISO]
- bHLH transcription factor binding [ISO]
- cAMP response element binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The chromatin remodeler Mi-2beta is required for CD4 expression and T cell development.
Changes in chromatin structure underlie the activation or silencing of genes during development. The chromatin remodeler Mi-2beta is highly expressed in thymocytes and is presumed to be a transcriptional repressor because of its presence in the nucleosome remodeling deacetylase (NuRD) complex. Using conditional inactivation, we show that Mi-2beta is required at several steps during T cell development: for differentiation of ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TCF12 EP300 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| EP300 TCF12 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.902 | BioGRID | 2687208 |
Curated By
- BioGRID