AURKA
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- mitotic cell cycle [TAS]
- mitotic nuclear division [TAS]
- mitotic spindle organization [IBA]
- negative regulation of protein binding [IDA]
- positive regulation of mitosis [TAS]
- protein autophosphorylation [TAS]
- protein phosphorylation [IDA]
- regulation of centrosome cycle [TAS]
- regulation of cytokinesis [IBA]
- regulation of protein stability [IMP]
- spindle stabilization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- centrosome [IDA, TAS]
- chromosome passenger complex [IBA]
- condensed nuclear chromosome, centromeric region [IBA]
- cytosol [TAS]
- microtubule cytoskeleton [IDA]
- midbody [TAS]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- spindle [TAS]
- spindle microtubule [IDA]
- spindle midzone [IBA]
- spindle pole centrosome [IDA]
HIST3H3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A.
Here we provide evidence in support of an inherent role for Arpc1b, a component of the Arp2/3 complex, in regulation of mitosis and demonstrate that its depletion inhibits Aurora A activation at the centrosome and impairs the ability of mammalian cells to enter mitosis. We discovered that Arpc1b colocalizes with gamma-tubulin at centrosomes and stimulates Aurora A activity. Aurora A ... [more]
Throughput
- Low Throughput
Additional Notes
- Arpc1b stimulates activity of Aurora A in vitro
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AURKA HIST3H3 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 610744 | |
| AURKA HIST3H3 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 858485 |
Curated By
- BioGRID