BAIT
HSP90AA1
EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP-2, LAP2
heat shock protein 90kDa alpha (cytosolic), class A member 1
GO Process (16)
GO Function (10)
GO Component (10)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- axon guidance [TAS]
- chaperone-mediated protein complex assembly [IDA]
- innate immune response [TAS]
- mitochondrial transport [TAS]
- mitotic cell cycle [TAS]
- nitric oxide metabolic process [TAS]
- positive regulation of nitric oxide biosynthetic process [ISS]
- protein import into mitochondrial outer membrane [IDA]
- protein refolding [TAS]
- regulation of nitric-oxide synthase activity [TAS]
- response to unfolded protein [NAS]
- signal transduction [NAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TGFBR2
TGF-beta 2, Tgfbr2T
transforming growth factor, beta receptor 2
GO Process (65)
GO Function (12)
GO Component (10)
Gene Ontology Biological Process
- activation of protein kinase activity [ISO]
- aging [IEP]
- apoptotic process [ISO]
- brain development [ISO]
- bronchus development [ISO]
- bronchus morphogenesis [ISO]
- cartilage development [ISO]
- common-partner SMAD protein phosphorylation [IDA]
- digestive tract development [IEP]
- embryo development [IEP]
- embryo implantation [IEP]
- embryonic cranial skeleton morphogenesis [ISO]
- embryonic hemopoiesis [ISO]
- gastrulation [ISO]
- growth plate cartilage chondrocyte growth [ISO]
- growth plate cartilage development [ISO]
- heart development [ISO]
- in utero embryonic development [ISO]
- lens development in camera-type eye [ISO]
- lens fiber cell apoptotic process [ISO]
- lung development [IEP, ISO]
- lung lobe morphogenesis [ISO]
- lung morphogenesis [ISO]
- mammary gland morphogenesis [ISO]
- myeloid dendritic cell differentiation [ISO]
- negative regulation of cardiac muscle cell proliferation [IMP]
- negative regulation of cell proliferation [IGI, IMP]
- organ morphogenesis [IMP]
- organ regeneration [IEP]
- palate development [ISO]
- pathway-restricted SMAD protein phosphorylation [ISO]
- patterning of blood vessels [ISO]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of B cell tolerance induction [ISO]
- positive regulation of NK T cell differentiation [ISO]
- positive regulation of T cell tolerance induction [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of epithelial cell migration [ISO]
- positive regulation of mesenchymal cell proliferation [ISO]
- positive regulation of reactive oxygen species metabolic process [ISO]
- positive regulation of skeletal muscle tissue regeneration [IEP]
- positive regulation of smooth muscle cell proliferation [IMP]
- positive regulation of tolerance induction to self antigen [ISO]
- protein phosphorylation [ISO]
- receptor-mediated endocytosis [IDA]
- regulation of cell proliferation [ISO]
- regulation of gene expression [ISO]
- response to cholesterol [ISO]
- response to drug [ISO]
- response to estrogen [IEP]
- response to glucose [IEP]
- response to hypoxia [IEP, TAS]
- response to mechanical stimulus [IEP]
- response to nutrient [IEP]
- response to organic cyclic compound [IEP]
- response to organic substance [IEP]
- response to steroid hormone [IEP]
- smoothened signaling pathway [ISO]
- trachea formation [ISO]
- trachea morphogenesis [ISO]
- transforming growth factor beta receptor signaling pathway [IMP, ISO, TAS]
- transmembrane receptor protein serine/threonine kinase signaling pathway [ISO]
- vasculogenesis [IEP, ISO]
- wound healing [IEP]
Gene Ontology Molecular Function- SMAD binding [ISO]
- glycosaminoglycan binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [TAS]
- protein homodimerization activity [TAS]
- transforming growth factor beta binding [ISO]
- transforming growth factor beta receptor activity, type II [IMP, TAS]
- transforming growth factor beta-activated receptor activity [ISO]
- transmembrane receptor protein serine/threonine kinase activity [ISO]
- type I transforming growth factor beta receptor binding [ISO]
- type III transforming growth factor beta receptor binding [ISO]
- SMAD binding [ISO]
- glycosaminoglycan binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [TAS]
- protein homodimerization activity [TAS]
- transforming growth factor beta binding [ISO]
- transforming growth factor beta receptor activity, type II [IMP, TAS]
- transforming growth factor beta-activated receptor activity [ISO]
- transmembrane receptor protein serine/threonine kinase activity [ISO]
- type I transforming growth factor beta receptor binding [ISO]
- type III transforming growth factor beta receptor binding [ISO]
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Heat shock protein 90 inhibitor attenuates renal fibrosis through degradation of transforming growth factor-β type II receptor.
The accumulation of extracellular matrix proteins in the interstitial area is the final common feature of chronic kidney diseases. Accumulating evidence suggests that transforming growth factor (TGF)-β1 promotes the development of renal fibrosis. Heat shock protein (Hsp) 90 inhibitors have been shown to repress TGF-β1 signaling, but whether they inhibit renal fibrosis is unknown. The purpose of this study is ... [more]
Lab. Invest. Nov. 01, 2012; 92(11);1583-96 [Pubmed: 22964853]
Throughput
- Low Throughput
Curated By
- BioGRID