CANX
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cellular protein metabolic process [TAS]
- clathrin-mediated endocytosis [ISS]
- post-translational protein modification [TAS]
- protein N-linked glycosylation via asparagine [TAS]
- protein folding [TAS]
- protein secretion [TAS]
- synaptic vesicle endocytosis [ISS]
Gene Ontology Molecular Function
SERPINF2
Gene Ontology Biological Process
- blood coagulation [TAS]
- blood vessel morphogenesis [ISS]
- collagen fibril organization [ISS]
- fibrinolysis [TAS]
- negative regulation of endopeptidase activity [IBA]
- negative regulation of fibrinolysis [IDA]
- negative regulation of plasminogen activation [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of JNK cascade [IDA]
- positive regulation of cell differentiation [IDA]
- positive regulation of cell-cell adhesion mediated by cadherin [TAS]
- positive regulation of collagen biosynthetic process [IDA]
- positive regulation of smooth muscle cell proliferation [ISS]
- positive regulation of stress fiber assembly [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transforming growth factor beta production [IDA]
- regulation of blood vessel size by renin-angiotensin [ISS]
- regulation of proteolysis [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Mannose trimming targets mutant alpha(2)-plasmin inhibitor for degradation by the proteasome.
We have previously characterized the molecular and cellular mechanisms of alpha(2)-plasmin inhibitor (alpha(2)PI) deficiency. The mutant alpha(2)PI-Nara and alpha(2)PI-Okinawa proteins were found to be retained and degraded in cells stably expressing these mutant forms of alpha(2)PI. Degradation of the two mutant alpha(2)PI proteins, mediated by proteasomes, occurred after a lag time of 1.5 h during which glucose trimming took place. ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID