BAIT
PIK3R2
MPPH, MPPH1, P85B, p85, p85-BETA
phosphoinositide-3-kinase, regulatory subunit 2 (beta)
GO Process (24)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- T cell receptor signaling pathway [TAS]
- blood coagulation [TAS]
- cellular glucose homeostasis [ISS]
- cellular response to insulin stimulus [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol 3-kinase signaling [IDA]
- phosphatidylinositol biosynthetic process [TAS]
- phosphatidylinositol-3-phosphate biosynthetic process [ISS]
- phosphatidylinositol-mediated signaling [TAS]
- phospholipid metabolic process [TAS]
- positive regulation of transcription factor import into nucleus [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- regulation of autophagy [IMP]
- regulation of small GTPase mediated signal transduction [TAS]
- response to endoplasmic reticulum stress [ISS]
- small GTPase mediated signal transduction [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
HSPA1L
HSP70-1L, HSP70-HOM, HSP70T, hum70t, DADB-333F21.5
heat shock 70kDa protein 1-like
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Charting the molecular network of the drug target Bcr-Abl.
The tyrosine kinase Bcr-Abl causes chronic myeloid leukemia and is the cognate target of tyrosine kinase inhibitors like imatinib. We have charted the protein-protein interaction network of Bcr-Abl by a 2-pronged approach. Using a monoclonal antibody we have first purified endogenous Bcr-Abl protein complexes from the CML K562 cell line and characterized the set of most tightly-associated interactors by MS. ... [more]
Proc. Natl. Acad. Sci. U.S.A. May. 05, 2009; 106(18);7414-9 [Pubmed: 19380743]
Throughput
- High Throughput
Ontology Terms
- cell line: k-562 cell (BTO:0000664) [chronic myeloid leukemia (DOID:8552)]
Additional Notes
- TAP-tagged PIK3R2
- exogenous expression of bait
Curated By
- BioGRID