ACVRL1
Gene Ontology Biological Process
- BMP signaling pathway [IMP]
- activin receptor signaling pathway [IDA]
- angiogenesis [IMP]
- artery development [ISS]
- blood circulation [IMP]
- blood vessel endothelial cell proliferation involved in sprouting angiogenesis [TAS]
- blood vessel maturation [TAS]
- blood vessel remodeling [ISS]
- cellular response to BMP stimulus [IMP]
- cellular response to transforming growth factor beta stimulus [IDA]
- endothelial tube morphogenesis [IMP]
- lymphangiogenesis [ISS]
- lymphatic endothelial cell differentiation [IMP]
- negative regulation of DNA biosynthetic process [IMP]
- negative regulation of blood vessel endothelial cell migration [IMP]
- negative regulation of cell adhesion [IMP]
- negative regulation of cell growth [IDA]
- negative regulation of cell migration [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of endothelial cell migration [IDA]
- negative regulation of focal adhesion assembly [IMP]
- positive regulation of BMP signaling pathway [IDA]
- positive regulation of chondrocyte differentiation [TAS]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein phosphorylation [IDA]
- regulation of DNA replication [TAS]
- regulation of blood pressure [IMP]
- regulation of blood vessel endothelial cell migration [TAS]
- regulation of endothelial cell proliferation [TAS]
- regulation of transcription, DNA-templated [IMP]
- retina vasculature development in camera-type eye [ISS]
- signal transduction [IDA]
- transforming growth factor beta receptor signaling pathway [IDA]
- venous blood vessel development [ISS]
- wound healing, spreading of epidermal cells [IMP]
Gene Ontology Molecular Function- ATP binding [IDA]
- SMAD binding [IDA]
- activin binding [IDA]
- activin receptor activity, type I [IDA, TAS]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA]
- transforming growth factor beta binding [IPI]
- transforming growth factor beta receptor activity, type I [IDA]
- transforming growth factor beta-activated receptor activity [IDA]
- transmembrane receptor protein serine/threonine kinase activity [NAS]
- ATP binding [IDA]
- SMAD binding [IDA]
- activin binding [IDA]
- activin receptor activity, type I [IDA, TAS]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA]
- transforming growth factor beta binding [IPI]
- transforming growth factor beta receptor activity, type I [IDA]
- transforming growth factor beta-activated receptor activity [IDA]
- transmembrane receptor protein serine/threonine kinase activity [NAS]
Gene Ontology Cellular Component
BAMBI
Gene Ontology Biological Process
- cell migration [IDA]
- negative regulation of transforming growth factor beta receptor signaling pathway [IDA, IMP, TAS]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of catenin import into nucleus [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of epithelial to mesenchymal transition [IMP]
- positive regulation of protein binding [IMP]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of cell shape [IMP]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
Transforming growth factor beta (TGF-beta) and related growth factors are essential regulators of embryogenesis and tissue homeostasis. The signaling pathways mediated by their receptors and Smad proteins are precisely modulated by various means. Xenopus BAMBI (bone morphogenic protein (BMP) and activin membrane-bound inhibitor) has been shown to function as a general negative regulator of TGF-beta/BMP/activin signaling. Here, we provide evidence ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID