BAIT
DRD2
D2DR, D2R
dopamine receptor D2
GO Process (54)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- adenohypophysis development [ISS]
- adenylate cyclase-inhibiting dopamine receptor signaling pathway [IDA]
- adult walking behavior [ISS]
- arachidonic acid secretion [IDA]
- associative learning [ISS]
- axonogenesis [ISS]
- behavioral response to cocaine [ISS]
- behavioral response to ethanol [ISS]
- branching morphogenesis of a nerve [ISS]
- cellular calcium ion homeostasis [IC]
- cerebral cortex GABAergic interneuron migration [ISS]
- circadian regulation of gene expression [ISS]
- dopamine metabolic process [IC]
- intracellular signal transduction [IDA]
- locomotory behavior [ISS]
- negative regulation of adenylate cyclase activity [IDA]
- negative regulation of blood pressure [ISS]
- negative regulation of cell migration [ISS]
- negative regulation of cell proliferation [ISS]
- negative regulation of dopamine receptor signaling pathway [ISS]
- negative regulation of protein kinase B signaling [ISS]
- negative regulation of protein secretion [IDA]
- negative regulation of synaptic transmission, glutamatergic [ISS]
- negative regulation of voltage-gated calcium channel activity [IDA]
- neurological system process involved in regulation of systemic arterial blood pressure [ISS]
- neuron-neuron synaptic transmission [ISS]
- peristalsis [ISS]
- phosphatidylinositol metabolic process [ISS]
- phospholipase C-activating dopamine receptor signaling pathway [IGI]
- positive regulation of cytokinesis [IMP]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [IDA]
- positive regulation of dopamine uptake involved in synaptic transmission [ISS]
- positive regulation of growth hormone secretion [ISS]
- positive regulation of neuroblast proliferation [ISS]
- prepulse inhibition [ISS]
- protein localization [ISS]
- regulation of cAMP metabolic process [IDA]
- regulation of dopamine uptake involved in synaptic transmission [IC]
- regulation of heart rate [ISS]
- regulation of long-term neuronal synaptic plasticity [ISS]
- regulation of potassium ion transport [ISS]
- regulation of sodium ion transport [ISS]
- regulation of synaptic transmission, GABAergic [ISS]
- release of sequestered calcium ion into cytosol [ISS]
- response to amphetamine [ISS]
- response to cocaine [ISS]
- response to drug [ISS]
- response to histamine [IDA]
- response to light stimulus [ISS]
- response to morphine [ISS]
- sensory perception of smell [ISS]
- synapse assembly [ISS]
- temperature homeostasis [ISS]
- visual learning [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PAWR
PAR4, Par-4
PRKC, apoptosis, WT1, regulator
GO Process (5)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Par-4 links dopamine signaling and depression.
Prostate apoptosis response 4 (Par-4) is a leucine zipper containing protein that plays a role in apoptosis. Although Par-4 is expressed in neurons, its physiological role in the nervous system is unknown. Here we identify Par-4 as a regulatory component in dopamine signaling. Par-4 directly interacts with the dopamine D2 receptor (D2DR) via the calmodulin binding motif in the third ... [more]
Cell Jul. 29, 2005; 122(2);275-87 [Pubmed: 16051151]
Throughput
- Low Throughput
Related interactions
Curated By
- BioGRID