BAIT

RAB11FIP4

RAB11-FIP4
RAB11 family interacting protein 4 (class II)
GO Process (1)
GO Function (4)
GO Component (6)
Homo sapiens
PREY

RAB11A

YL8
RAB11A, member RAS oncogene family
GO Process (24)
GO Function (7)
GO Component (12)
Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis.

Fielding AB, Schonteich E, Matheson J, Wilson G, Yu X, Hickson GR, Srivastava S, Baldwin SA, Prekeris R, Gould GW

The dual Rab11/Arf binding proteins, family of Rab11-interacting proteins FIP3 and FIP4 function in the delivery of recycling endosomes to the cleavage furrow and are, together with Rab11, essential for completion of abscission, the terminal step of cytokinesis. Here, we report that both FIP3 and FIP4 bind Arf6 in a nucleotide-dependent manner but exhibit differential affinities for Rab11 and Arf6. ... [more]

EMBO J. Oct. 05, 2005; 24(19);3389-99 [Pubmed: 16148947]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
RAB11FIP4 RAB11A
Far Western
Far Western

An interaction is detected between a protein immobilized on a membrane and a purified protein probe.

Low-BioGRID
-
RAB11FIP4 RAB11A
Two-hybrid
Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Low-BioGRID
-

Curated By

  • BioGRID