BAIT
CAV1
BSCL3, CGL3, LCCNS, MSTP085, PPH3, VIP21
caveolin 1, caveolae protein, 22kDa
GO Process (65)
GO Function (13)
GO Component (15)
Gene Ontology Biological Process
- T cell costimulation [IDA]
- apoptotic signaling pathway [IMP]
- blood coagulation [TAS]
- calcium ion homeostasis [ISS]
- calcium ion transport [ISS]
- caveola assembly [IGI, IMP]
- caveolin-mediated endocytosis [IDA]
- cellular calcium ion homeostasis [ISS]
- cellular response to hyperoxia [IMP]
- cellular response to starvation [IEP]
- cholesterol homeostasis [ISS, TAS]
- cholesterol transport [TAS]
- cytosolic calcium ion homeostasis [IDA]
- inactivation of MAPK activity [ISS]
- leukocyte migration [TAS]
- lipid storage [ISS]
- maintenance of protein location in cell [ISS]
- mammary gland development [ISS]
- mammary gland involution [ISS]
- membrane depolarization [ISS]
- negative regulation of BMP signaling pathway [IDA]
- negative regulation of JAK-STAT cascade [ISS]
- negative regulation of MAPK cascade [ISS]
- negative regulation of anoikis [IMP]
- negative regulation of canonical Wnt signaling pathway [ISS]
- negative regulation of endothelial cell proliferation [ISS]
- negative regulation of epithelial cell differentiation [ISS]
- negative regulation of nitric oxide biosynthetic process [ISS]
- negative regulation of peptidyl-serine phosphorylation [IDA]
- negative regulation of peptidyl-tyrosine autophosphorylation [IMP]
- negative regulation of pinocytosis [IMP]
- negative regulation of potassium ion transmembrane transport [IMP]
- negative regulation of protein binding [IDA]
- negative regulation of protein tyrosine kinase activity [IMP]
- negative regulation of protein ubiquitination [IMP]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- nitric oxide homeostasis [ISS]
- nitric oxide metabolic process [TAS]
- positive regulation of calcium ion transport into cytosol [ISS]
- positive regulation of canonical Wnt signaling pathway [IMP]
- positive regulation of extrinsic apoptotic signaling pathway [IMP]
- positive regulation of intrinsic apoptotic signaling pathway [IMP]
- positive regulation of metalloenzyme activity [ISS]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of vasoconstriction [ISS]
- protein homooligomerization [ISS]
- protein localization [ISS]
- receptor internalization involved in canonical Wnt signaling pathway [IMP]
- regulation of blood coagulation [IMP]
- regulation of cardiac muscle cell action potential involved in regulation of contraction [IC]
- regulation of fatty acid metabolic process [ISS]
- regulation of inward rectifier potassium channel activity [IMP]
- regulation of membrane repolarization during action potential [IMP]
- regulation of nitric-oxide synthase activity [TAS]
- regulation of peptidase activity [ISS]
- regulation of smooth muscle contraction [ISS]
- response to calcium ion [ISS]
- response to estrogen [IDA]
- response to hypoxia [ISS]
- response to progesterone [IDA]
- skeletal muscle tissue development [ISS]
- small molecule metabolic process [TAS]
- triglyceride metabolic process [ISS]
- vasculogenesis [ISS]
- vesicle organization [IDA]
Gene Ontology Molecular Function- cholesterol binding [TAS]
- enzyme binding [IPI]
- identical protein binding [IPI]
- inward rectifier potassium channel inhibitor activity [IDA]
- ion channel binding [IPI]
- nitric-oxide synthase binding [IPI]
- patched binding [NAS]
- peptidase activator activity [ISS]
- protein binding [IPI]
- protein complex scaffold [TAS]
- protein kinase binding [IPI]
- receptor binding [IPI]
- structural molecule activity [IDA]
- cholesterol binding [TAS]
- enzyme binding [IPI]
- identical protein binding [IPI]
- inward rectifier potassium channel inhibitor activity [IDA]
- ion channel binding [IPI]
- nitric-oxide synthase binding [IPI]
- patched binding [NAS]
- peptidase activator activity [ISS]
- protein binding [IPI]
- protein complex scaffold [TAS]
- protein kinase binding [IPI]
- receptor binding [IPI]
- structural molecule activity [IDA]
Gene Ontology Cellular Component
- Golgi membrane [IDA, TAS]
- apical plasma membrane [IDA]
- basolateral plasma membrane [IDA]
- caveola [IDA, NAS]
- cytoplasmic vesicle [IDA]
- endocytic vesicle membrane [TAS]
- endoplasmic reticulum [IDA]
- endosome [IDA]
- focal adhesion [IDA]
- intracellular [IDA]
- lipid particle [TAS]
- membrane raft [IDA]
- perinuclear region of cytoplasm [IDA, ISS]
- plasma membrane [IDA, TAS]
- protein complex [IDA]
Homo sapiens
PREY
SNCA
NACP, PARK1, PARK4, PD1
synuclein, alpha (non A4 component of amyloid precursor)
GO Process (45)
GO Function (20)
GO Component (16)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- calcium ion homeostasis [IDA]
- cellular response to copper ion [IDA]
- cellular response to epinephrine stimulus [TAS]
- cellular response to oxidative stress [IC]
- dopamine biosynthetic process [TAS]
- dopamine uptake involved in synaptic transmission [TAS]
- extracellular fibril organization [TAS]
- microglial cell activation [TAS]
- negative regulation of apoptotic process [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of dopamine uptake involved in synaptic transmission [IDA]
- negative regulation of exocytosis [IMP]
- negative regulation of histone acetylation [IDA]
- negative regulation of microtubule polymerization [IDA]
- negative regulation of mitochondrial electron transport, NADH to ubiquinone [TAS]
- negative regulation of monooxygenase activity [IDA]
- negative regulation of norepinephrine uptake [IDA]
- negative regulation of platelet-derived growth factor receptor signaling pathway [IDA]
- negative regulation of serotonin uptake [IDA]
- negative regulation of thrombin receptor signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- negative regulation of transporter activity [IDA]
- oxidation-reduction process [IDA]
- positive regulation of apoptotic process [TAS]
- positive regulation of endocytosis [IDA]
- positive regulation of glutathione peroxidase activity [IDA]
- positive regulation of hydrogen peroxide catabolic process [IDA]
- positive regulation of inositol phosphate biosynthetic process [IDA]
- positive regulation of peptidyl-serine phosphorylation [ISS]
- positive regulation of protein serine/threonine kinase activity [IDA]
- positive regulation of receptor recycling [IDA]
- positive regulation of release of sequestered calcium ion into cytosol [IDA]
- protein destabilization [IDA]
- receptor internalization [IDA]
- regulation of dopamine secretion [TAS]
- regulation of phospholipase activity [IDA]
- regulation of reactive oxygen species biosynthetic process [TAS]
- regulation of synaptic vesicle recycling [TAS]
- response to interferon-gamma [IDA]
- response to interleukin-1 [IDA]
- response to iron(II) ion [IDA]
- response to lipopolysaccharide [IDA]
- response to magnesium ion [IDA]
- synaptic vesicle endocytosis [ISS]
Gene Ontology Molecular Function- Hsp70 protein binding [IPI]
- alpha-tubulin binding [IPI]
- calcium ion binding [IDA]
- copper ion binding [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IDA]
- dynein binding [IPI]
- fatty acid binding [IDA]
- ferrous iron binding [IDA]
- histone binding [IDA]
- identical protein binding [IPI]
- kinesin binding [IPI]
- magnesium ion binding [IDA]
- oxidoreductase activity [IDA]
- phospholipase D inhibitor activity [IDA]
- phospholipid binding [IDA]
- phosphoprotein binding [IDA]
- protein binding [IPI]
- tau protein binding [IDA]
- transcription regulatory region DNA binding [TAS]
- zinc ion binding [IDA]
- Hsp70 protein binding [IPI]
- alpha-tubulin binding [IPI]
- calcium ion binding [IDA]
- copper ion binding [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IDA]
- dynein binding [IPI]
- fatty acid binding [IDA]
- ferrous iron binding [IDA]
- histone binding [IDA]
- identical protein binding [IPI]
- kinesin binding [IPI]
- magnesium ion binding [IDA]
- oxidoreductase activity [IDA]
- phospholipase D inhibitor activity [IDA]
- phospholipid binding [IDA]
- phosphoprotein binding [IDA]
- protein binding [IPI]
- tau protein binding [IDA]
- transcription regulatory region DNA binding [TAS]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
- actin cytoskeleton [IDA]
- axon [IDA]
- cell cortex [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- extracellular region [TAS]
- fibril [IDA]
- growth cone [IDA]
- inclusion body [IDA]
- lysosome [TAS]
- mitochondrial respiratory chain complex I [TAS]
- mitochondrion [TAS]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- platelet alpha granule membrane [IDA]
Homo sapiens
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Caveolin-1 interacts with alpha-synuclein and mediates toxic actions of cellular alpha-synuclein overexpression.
Caveolin-1 (Cav-1) is a transmembrane protein which clusters proteins and lipids at the cell membrane into a subclass of lipid rafts named caveolae. To increase our understanding about putative functions of Cav-1 in neuronal cells, we used mouse brain extracts and a novel technology coupling surface plasmon resonance to mass spectrometry to find binding partners to Cav-1. An interaction between ... [more]
Neurochem. Int. Aug. 01, 2011; 59(2);280-9 [Pubmed: 21693152]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SNCA CAV1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | 4 | BioGRID | 3777574 |
Curated By
- BioGRID