Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

Publication

A Genetic Screen to Discover Pathways Affecting Cohesin Function in Schizosaccharomyces pombe Identifies Chromatin Effectors.

Chen Z, McCrosky S, Guo W, Li H, Gerton JL

Cohesion, the force that holds sister chromatids together from the time of DNA replication until separation at the metaphase to anaphase transition, is mediated by the cohesin complex. This complex is also involved in DNA damage repair, chromosomes condensation, and gene regulation. To learn more about the cellular functions of cohesin, we conducted a genetic screen in Schizosaccharomyces pombe with ... [more]

G3 (Bethesda) Oct. 01, 2012; 2(10);1161-8 [Pubmed: 23050226]

Throughput

High Throughput

Ontology Terms

phenotype: colony size (APO:0000063)

Additional Notes

significant negative interaction with the eso1-G799D mutant

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
ESO1 RAD8	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Coulon S (2010)	Low	-	BioGRID	439092

Curated By

BioGRID

Interaction Summary

ESO1

Gene Ontology Biological Process

Gene Ontology Molecular Function

DNA-directed DNA polymerase activity [ISO]acetyltransferase activity [ISS]peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [IMP]protein binding [IPI]

Gene Ontology Cellular Component

RAD8