ASIC2
Gene Ontology Biological Process
- cation transmembrane transport [IMP]
- cation transport [IDA, IMP]
- cellular response to acidic pH [ISO]
- cellular response to drug [ISO]
- detection of mechanical stimulus involved in sensory perception [IMP]
- ion transmembrane transport [IDA, IMP]
- negative regulation of apoptotic process [IMP]
- phototransduction [IMP]
- positive regulation of cation channel activity [ISO]
- positive regulation of synapse assembly [IMP]
- protein localization to synapse [IMP]
- regulation of blood coagulation [ISO]
- regulation of gene expression [ISO]
- regulation of ion transmembrane transport [IMP]
- regulation of membrane potential [IMP]
- regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback [IMP]
- regulation of vasoconstriction [IMP]
- response to acidic pH [IDA, IMP]
- response to mechanical stimulus [IMP]
- sensory perception of sound [IMP]
- sensory perception of sour taste [ISO]
- sodium ion transmembrane transport [IDA, ISO]
- sodium ion transport [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ASIC1
Gene Ontology Biological Process
- associative learning [IMP]
- calcium ion transmembrane transport [IMP]
- cation transmembrane transport [IDA]
- cation transport [IDA, IMP]
- cellular response to pH [ISO]
- ion transmembrane transport [IDA, IMP, ISO]
- memory [IMP]
- monovalent inorganic cation transport [ISO]
- negative regulation of neurotransmitter secretion [IMP]
- regulation of membrane potential [IMP]
- response to acidic pH [IDA, IMP]
- sensory perception of sour taste [ISO]
- sodium ion transmembrane transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
ASIC2 subunits target acid-sensing ion channels to the synapse via an association with PSD-95.
Acid-sensing ion channel-1a (ASIC1a) mediates H(+)-gated current to influence normal brain physiology and impact several models of disease. Although ASIC2 subunits are widely expressed in brain and modulate ASIC1a current, their function remains poorly understood. We identified ASIC2a in dendrites, dendritic spines, and brain synaptosomes. This localization largely relied on ASIC2a binding to PSD-95 and matched that of ASIC1a, which ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ASIC1 ASIC2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 736836 |
Curated By
- BioGRID