BAIT
MED21
0610007L03Rik, AI449604, D19234, D6Ertd782e, Srb7, Surb7, RP23-158O11.4
mediator complex subunit 21
GO Process (5)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PIK3CA
6330412C24Rik, caPI3K, p110, p110alpha
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
GO Process (13)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- glucose metabolic process [IMP]
- hypomethylation of CpG island [IDA]
- negative regulation of anoikis [ISO]
- negative regulation of fibroblast apoptotic process [IDA]
- negative regulation of neuron apoptotic process [IMP]
- phosphatidylinositol phosphorylation [IBA, ISO]
- phosphatidylinositol-3-phosphate biosynthetic process [ISO]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of protein kinase activity [IDA]
- protein kinase B signaling [IMP]
- protein phosphorylation [IDA]
- regulation of genetic imprinting [IDA]
- regulation of multicellular organism growth [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways.
A multiprotein complex isolated from murine cells is identified as a counterpart of the yeast Mediator of transcriptional regulation on the basis of the following: homologs of two subunits of yeast Mediator, Srb7 and Med7, copurify with the complex; peptide sequencing reveals, in addition, homologs of the yeast Mediator subunits Rgr1 and Med6; as with yeast Mediator, the mouse complex ... [more]
Proc. Natl. Acad. Sci. U.S.A. Jul. 21, 1998; 95(15);8538-43 [Pubmed: 9671713]
Throughput
- Low Throughput
Curated By
- BioGRID