BAIT
INS
IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10
insulin
GO Process (60)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- MAPK cascade [IDA]
- activation of protein kinase B activity [IDA]
- acute-phase response [IDA]
- alpha-beta T cell activation [IDA]
- cell-cell signaling [IC]
- cellular protein metabolic process [TAS]
- endocrine pancreas development [TAS]
- energy reserve metabolic process [TAS]
- fatty acid homeostasis [IMP]
- glucose homeostasis [IMP]
- glucose transport [IDA]
- insulin receptor signaling pathway [TAS]
- negative regulation of NAD(P)H oxidase activity [IDA]
- negative regulation of acute inflammatory response [IDA]
- negative regulation of fatty acid metabolic process [IMP]
- negative regulation of feeding behavior [IDA]
- negative regulation of gluconeogenesis [NAS]
- negative regulation of glycogen catabolic process [IMP]
- negative regulation of lipid catabolic process [IMP, NAS]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [NAS]
- negative regulation of protein catabolic process [IDA]
- negative regulation of protein oligomerization [IDA]
- negative regulation of protein secretion [IDA]
- negative regulation of proteolysis [IMP]
- negative regulation of respiratory burst involved in inflammatory response [IDA]
- negative regulation of vasodilation [NAS]
- positive regulation of DNA replication [IDA]
- positive regulation of MAPK cascade [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of brown fat cell differentiation [TAS]
- positive regulation of cell differentiation [NAS]
- positive regulation of cell growth [NAS]
- positive regulation of cell migration [ISS]
- positive regulation of cell proliferation [IDA]
- positive regulation of cellular protein metabolic process [IMP]
- positive regulation of cytokine secretion [IDA]
- positive regulation of glucose import [IDA]
- positive regulation of glycogen biosynthetic process [IDA]
- positive regulation of glycolytic process [IDA, IMP]
- positive regulation of insulin receptor signaling pathway [IDA]
- positive regulation of lipid biosynthetic process [NAS]
- positive regulation of mitosis [IDA]
- positive regulation of nitric oxide biosynthetic process [NAS]
- positive regulation of nitric-oxide synthase activity [NAS]
- positive regulation of peptide hormone secretion [TAS]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of protein autophosphorylation [ISS]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of respiratory burst [IDA]
- positive regulation of vasodilation [NAS]
- regulation of cellular amino acid metabolic process [IMP]
- regulation of insulin secretion [TAS]
- regulation of protein localization [IDA]
- regulation of protein secretion [IDA]
- regulation of transcription, DNA-templated [NAS]
- regulation of transmembrane transporter activity [IDA]
- small molecule metabolic process [TAS]
- wound healing [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
APP
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2
amyloid beta (A4) precursor protein
GO Process (29)
GO Function (8)
GO Component (21)
Gene Ontology Biological Process
- adult locomotory behavior [ISS]
- axon cargo transport [ISS]
- axon midline choice point recognition [ISS]
- axonogenesis [ISS]
- blood coagulation [TAS]
- cellular copper ion homeostasis [ISS]
- collateral sprouting in absence of injury [ISS]
- dendrite development [ISS]
- endocytosis [ISS]
- extracellular matrix organization [ISS, TAS]
- innate immune response [TAS]
- ionotropic glutamate receptor signaling pathway [ISS]
- locomotory behavior [ISS]
- mRNA polyadenylation [ISS]
- mating behavior [ISS]
- negative regulation of endopeptidase activity [IDA]
- neuron apoptotic process [IMP]
- neuron projection development [ISS]
- neuron remodeling [ISS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of mitotic cell cycle [ISS]
- protein phosphorylation [ISS]
- regulation of epidermal growth factor-activated receptor activity [ISS]
- regulation of multicellular organism growth [ISS]
- regulation of synapse structure or activity [ISS]
- regulation of translation [ISS]
- visual learning [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISS]
- axon [ISS]
- cell surface [IDA]
- cytoplasm [IDA, ISS]
- cytosol [TAS]
- dendritic shaft [IDA]
- dendritic spine [IDA]
- endosome [IDA]
- extracellular region [TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- integral component of membrane [ISS]
- integral component of plasma membrane [TAS]
- intracellular membrane-bounded organelle [IDA]
- membrane raft [IDA]
- nuclear envelope lumen [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- platelet alpha granule lumen [TAS]
- receptor complex [IDA]
- synapse [IDA]
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein.
The disordered tubulin polymerization promoting protein (TPPP/p25) was found to be co-enriched in neuronal and glial inclusions with α-synuclein in Parkinson disease and multiple system atrophy, respectively; however, co-occurrence of α-synuclein with β-amyloid (Aβ) in human brain inclusions has been recently reported, suggesting the existence of mixed type pathologies that could result in obstacles in the correct diagnosis and treatment. ... [more]
J. Biol. Chem. Sep. 30, 2011; 286(39);34088-100 [Pubmed: 21832049]
Throughput
- High Throughput
Curated By
- BioGRID