WNT4
Gene Ontology Biological Process
- adrenal gland development [IEP]
- androgen biosynthetic process [IDA]
- canonical Wnt signaling pathway [IDA]
- cell fate commitment [IBA]
- cellular response to transforming growth factor beta stimulus [IEP]
- epithelial to mesenchymal transition [IEP]
- establishment of protein localization to plasma membrane [IDA]
- female gonad development [ISS]
- female sex determination [IMP]
- kidney development [IEP]
- liver development [IEP]
- male gonad development [IEP, IMP]
- mammary gland epithelium development [IEP]
- metanephric mesenchymal cell differentiation [NAS]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of gene expression [IDA]
- negative regulation of male gonad development [IMP]
- negative regulation of steroid biosynthetic process [IDA]
- negative regulation of testicular blood vessel morphogenesis [IMP]
- negative regulation of testosterone biosynthetic process [IMP]
- negative regulation of transcription, DNA-templated [IMP, ISS]
- neuron differentiation [IBA]
- non-canonical Wnt signaling pathway via MAPK cascade [IDA]
- paramesonephric duct development [IMP]
- positive regulation of aldosterone biosynthetic process [IDA]
- positive regulation of bone mineralization [IDA]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of collagen biosynthetic process [IDA]
- positive regulation of cortisol biosynthetic process [IDA]
- positive regulation of dermatome development [IDA]
- positive regulation of osteoblast differentiation [IDA]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- protein palmitoylation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
APP
Gene Ontology Biological Process
- adult locomotory behavior [ISS]
- axon cargo transport [ISS]
- axon midline choice point recognition [ISS]
- axonogenesis [ISS]
- blood coagulation [TAS]
- cellular copper ion homeostasis [ISS]
- collateral sprouting in absence of injury [ISS]
- dendrite development [ISS]
- endocytosis [ISS]
- extracellular matrix organization [ISS, TAS]
- innate immune response [TAS]
- ionotropic glutamate receptor signaling pathway [ISS]
- locomotory behavior [ISS]
- mRNA polyadenylation [ISS]
- mating behavior [ISS]
- negative regulation of endopeptidase activity [IDA]
- neuron apoptotic process [IMP]
- neuron projection development [ISS]
- neuron remodeling [ISS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of mitotic cell cycle [ISS]
- protein phosphorylation [ISS]
- regulation of epidermal growth factor-activated receptor activity [ISS]
- regulation of multicellular organism growth [ISS]
- regulation of synapse structure or activity [ISS]
- regulation of translation [ISS]
- visual learning [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISS]
- axon [ISS]
- cell surface [IDA]
- cytoplasm [IDA, ISS]
- cytosol [TAS]
- dendritic shaft [IDA]
- dendritic spine [IDA]
- endosome [IDA]
- extracellular region [TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- integral component of membrane [ISS]
- integral component of plasma membrane [TAS]
- intracellular membrane-bounded organelle [IDA]
- membrane raft [IDA]
- nuclear envelope lumen [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- platelet alpha granule lumen [TAS]
- receptor complex [IDA]
- synapse [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein.
The disordered tubulin polymerization promoting protein (TPPP/p25) was found to be co-enriched in neuronal and glial inclusions with α-synuclein in Parkinson disease and multiple system atrophy, respectively; however, co-occurrence of α-synuclein with β-amyloid (Aβ) in human brain inclusions has been recently reported, suggesting the existence of mixed type pathologies that could result in obstacles in the correct diagnosis and treatment. ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| WNT4 APP | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.4091 | BioGRID | 3245887 |
Curated By
- BioGRID