BAIT
A2M
A2MD, CPAMD5, FWP007, S863-7
alpha-2-macroglobulin
GO Process (10)
GO Function (10)
GO Component (5)
Gene Ontology Biological Process
- blood coagulation [TAS]
- blood coagulation, intrinsic pathway [TAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- negative regulation of complement activation, lectin pathway [IDA]
- negative regulation of endopeptidase activity [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MLST8
GBL, GbetaL, LST8, POP3, WAT1
MTOR associated protein, LST8 homolog (S. cerevisiae)
GO Process (10)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- T cell costimulation [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of TOR signaling [IMP]
- regulation of actin cytoskeleton organization [IMP]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Interactome mapping suggests new mechanistic details underlying Alzheimer's disease.
Recent advances toward the characterization of Alzheimer's disease (AD) have permitted the identification of a dozen of genetic risk factors, although many more remain undiscovered. In parallel, works in the field of network biology have shown a strong link between protein connectivity and disease. In this manuscript, we demonstrate that AD-related genes are indeed highly interconnected and, based on this ... [more]
Genome Res. Mar. 01, 2011; 21(3);364-76 [Pubmed: 21163940]
Throughput
- Low Throughput
Curated By
- BioGRID