A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1.

Saka Y, Esashi F, Matsusaka T, Mochida S, Yanagida M

Fission yeast Cut5/Rad4 plays a unique role in the genome maintenance as it is required for replication, replication checkpoint, and normal UV sensitivity. It is unknown, however, how Cut5 protein is linked to other checkpoint proteins, and what part it plays in replication and UV sensitivity. Here we report that Cut5 interacts with a novel checkpoint protein Crb2 and that ... [more]

Genes Dev. Dec. 15, 1997; 11(24);3387-400 [Pubmed: 9407031]

Throughput

Low Throughput

Ontology Terms

phenotype: cell cycle progression (APO:0000253)

Additional Notes

deletion of crb2 abolishes the cell cycle arrest of the single mutant and the increase in SI

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
CRB2 POL1	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Grenon M (1999)	Low	-	BioGRID	247057
POL1 CRB2	Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Mochida S (2004)	Low	-	BioGRID	798430
CRB2 POL1	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Grenon M (1999)	Low	-	BioGRID	247064

Curated By

BioGRID

Interaction Summary

POL1

Gene Ontology Biological Process

Gene Ontology Molecular Function

DNA replication origin binding [IDA]DNA-directed DNA polymerase activity [IDA, IGI]chromatin binding [IDA]protein binding [IPI]single-stranded DNA binding [IDA]

Gene Ontology Cellular Component

CRB2