BAIT

RHEB

RHEB2
Ras homolog enriched in brain
Alzheimer's Disease Project
GO Process (4)
GO Function (3)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

RABAC1

PRA1, PRAF1, YIP3
Rab acceptor 1 (prenylated)
GO Process (0)
GO Function (2)
GO Component (1)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb.

Li Y, Wang Y, Kim E, Beemiller P, Wang CY, Swanson J, You M, Guan KL

The mammalian target of rapamycin (mTOR) is a central controller of cell growth, and it regulates translation, cell size, cell viability, and cell morphology. mTOR integrates a wide range of extracellular and intracellular signals, including growth factors, nutrients, energy levels, and stress conditions. Rheb, a Ras-related small GTPase, is a key upstream activator of mTOR. In this study, we found ... [more]

J. Biol. Chem. Dec. 07, 2007; 282(49);35803-13 [Pubmed: 17928295]

Throughput

  • Low Throughput

Curated By

  • BioGRID