CASP1
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [TAS]
- apoptotic process [TAS]
- cellular response to mechanical stimulus [IEP]
- cellular response to organic substance [IDA]
- execution phase of apoptosis [IBA]
- innate immune response [TAS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP]
- proteolysis [IDA]
- regulation of inflammatory response [IBA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
IL1B
Gene Ontology Biological Process
- MAPK cascade [IMP]
- activation of MAPK activity [IDA]
- apoptotic process [TAS]
- cell-cell signaling [TAS]
- cellular response to drug [IDA]
- cellular response to mechanical stimulus [IEP]
- cellular response to organic cyclic compound [IDA]
- cellular response to organic substance [IDA]
- cytokine-mediated signaling pathway [IDA]
- embryo implantation [TAS]
- hyaluronan biosynthetic process [IDA]
- inflammatory response [IDA, NAS]
- lipopolysaccharide-mediated signaling pathway [IDA]
- monocyte aggregation [IDA]
- negative regulation of MAP kinase activity [ISS]
- negative regulation of adiponectin secretion [ISS]
- negative regulation of cell proliferation [IDA]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- negative regulation of glucose transport [ISS]
- negative regulation of insulin receptor signaling pathway [ISS]
- negative regulation of lipid catabolic process [IDA]
- negative regulation of lipid metabolic process [ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IBA]
- positive regulation of JNK cascade [IBA]
- positive regulation of NF-kappaB import into nucleus [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of T cell mediated immunity [IC]
- positive regulation of T cell proliferation [IDA]
- positive regulation of angiogenesis [ISS]
- positive regulation of calcidiol 1-monooxygenase activity [IDA]
- positive regulation of cell adhesion molecule production [NAS]
- positive regulation of fever generation [ISS]
- positive regulation of gene expression [IDA]
- positive regulation of granulocyte macrophage colony-stimulating factor production [IDA]
- positive regulation of heterotypic cell-cell adhesion [IDA, NAS]
- positive regulation of histone acetylation [NAS]
- positive regulation of histone phosphorylation [NAS]
- positive regulation of interferon-gamma production [IDA]
- positive regulation of interleukin-2 biosynthetic process [IMP]
- positive regulation of interleukin-6 production [TAS]
- positive regulation of interleukin-8 production [IDA]
- positive regulation of lipid catabolic process [ISS]
- positive regulation of membrane protein ectodomain proteolysis [IDA]
- positive regulation of mitosis [IMP]
- positive regulation of monocyte chemotactic protein-1 production [IDA]
- positive regulation of myosin light chain kinase activity [IDA]
- positive regulation of nitric oxide biosynthetic process [IDA]
- positive regulation of prostaglandin secretion [ISS]
- positive regulation of protein export from nucleus [NAS]
- positive regulation of protein phosphorylation [IDA, NAS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IC]
- positive regulation vascular endothelial growth factor production [IDA, ISS]
- protein kinase B signaling [IMP]
- regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- regulation of insulin secretion [IDA]
- sequestering of triglyceride [IDA]
- signal transduction [TAS]
- smooth muscle adaptation [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Proteolytic Processing)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Cleavage of poly(ADP-ribose) polymerase by interleukin-1 beta converting enzyme and its homologs TX and Nedd-2.
The proteolytic cleavage of poly(ADP-ribose) polymerase (PARP) is an early biochemical event, which occurs during apoptosis. A recent study suggested that PARP cleavage can be mediated by a novel cytosolic protease (prICE) that resembles interleukin-1 beta converting enzyme (ICE), but cannot be mediated by ICE itself (Lazebnik, Y.A., Kaufmann, S.H., Desnoyers, S., Poirier, G.G., and Earnshaw, W.C. (1994) Nature 371, ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CASP1 IL1B | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 2906832 | |
| CASP1 IL1B | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 2468100 |
Curated By
- BioGRID