BAIT
AGTR1
AG2S, AGTR1B, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, HAT1R
angiotensin II receptor, type 1
GO Process (27)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- Rho protein signal transduction [IDA]
- angiotensin-activated signaling pathway [IDA]
- calcium-mediated signaling [IDA]
- cell chemotaxis [IDA]
- kidney development [IMP]
- low-density lipoprotein particle remodeling [NAS]
- phospholipase C-activating G-protein coupled receptor signaling pathway [NAS]
- phospholipase C-activating angiotensin-activated signaling pathway [IDA, IPI]
- positive regulation of NAD(P)H oxidase activity [TAS]
- positive regulation of cellular protein metabolic process [IMP]
- positive regulation of cholesterol esterification [IMP]
- positive regulation of cytosolic calcium ion concentration [IDA]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [IDA]
- positive regulation of inflammatory response [TAS]
- positive regulation of macrophage derived foam cell differentiation [IC]
- positive regulation of phospholipase A2 activity [IMP]
- positive regulation of reactive oxygen species metabolic process [TAS]
- regulation of blood vessel size by renin-angiotensin [IC]
- regulation of cell growth [NAS]
- regulation of cell proliferation [NAS]
- regulation of inflammatory response [IC]
- regulation of renal sodium excretion [NAS]
- regulation of systemic arterial blood pressure by renin-angiotensin [IC]
- regulation of vasoconstriction [IC, IDA, NAS]
- regulation of vasodilation [IC]
- renin-angiotensin regulation of aldosterone production [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
JAK2
JTK10, THCYT3
Janus kinase 2
GO Process (49)
GO Function (12)
GO Component (7)
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [ISS, TAS]
- STAT protein import into nucleus [ISS]
- actin filament polymerization [NAS]
- activation of JAK2 kinase activity [ISS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISS]
- activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [ISS]
- apoptotic process [ISS]
- blood coagulation [TAS]
- cell differentiation [ISS]
- cell migration [IBA]
- cellular component movement [TAS]
- cytokine-mediated signaling pathway [IDA, ISS, TAS]
- enzyme linked receptor protein signaling pathway [ISS]
- erythrocyte differentiation [IBA, ISS]
- extrinsic apoptotic signaling pathway [ISS]
- growth hormone receptor signaling pathway [IDA]
- histone H3-Y41 phosphorylation [IDA]
- innate immune response [IBA]
- interferon-gamma-mediated signaling pathway [TAS]
- interleukin-12-mediated signaling pathway [IDA]
- intracellular signal transduction [ISS]
- mammary gland epithelium development [ISS]
- mesoderm development [TAS]
- negative regulation of DNA binding [ISS]
- negative regulation of cell proliferation [ISS]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [ISS]
- positive regulation of cell-substrate adhesion [IDA]
- positive regulation of growth hormone receptor signaling pathway [ISS]
- positive regulation of nitric-oxide synthase biosynthetic process [ISS]
- positive regulation of peptidyl-tyrosine phosphorylation [ISS]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISS]
- positive regulation of tumor necrosis factor production [ISS]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISS]
- positive regulation of tyrosine phosphorylation of Stat5 protein [ISS]
- protein autophosphorylation [ISS]
- protein phosphorylation [TAS]
- regulation of apoptotic process [IBA]
- regulation of cell proliferation [IBA]
- regulation of inflammatory response [IDA]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- response to antibiotic [IDA]
- response to interleukin-12 [IDA]
- response to lipopolysaccharide [ISS]
- response to tumor necrosis factor [IDA]
- signal transduction [ISS]
- tumor necrosis factor-mediated signaling pathway [IDA]
- tyrosine phosphorylation of STAT protein [IBA, ISS]
Gene Ontology Molecular Function- SH2 domain binding [IPI]
- growth hormone receptor binding [IBA, ISS]
- heme binding [IDA]
- histone binding [IDA]
- histone kinase activity (H3-Y41 specific) [IDA]
- interleukin-12 receptor binding [ISS]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- protein binding [IPI]
- protein kinase activity [NAS]
- protein kinase binding [IDA]
- protein tyrosine kinase activity [EXP, ISS, TAS]
- receptor binding [IPI]
- SH2 domain binding [IPI]
- growth hormone receptor binding [IBA, ISS]
- heme binding [IDA]
- histone binding [IDA]
- histone kinase activity (H3-Y41 specific) [IDA]
- interleukin-12 receptor binding [ISS]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- protein binding [IPI]
- protein kinase activity [NAS]
- protein kinase binding [IDA]
- protein tyrosine kinase activity [EXP, ISS, TAS]
- receptor binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The angiotensin II-dependent nuclear translocation of Stat1 is mediated by the Jak2 protein motif 231YRFRR.
In response to angiotensin II, Jak2 autophosphorylates and binds the angiotensin II AT(1) receptor. By studying a variety of Jak2 deletion proteins, we now show that the Jak2 protein motif (231)YRFRR is required for the co-association of this kinase with the AT(1) receptor. We also used a full-length Jak2 protein containing a (231)FAAAA amino acid substitution. Although this protein still ... [more]
J. Biol. Chem. Mar. 30, 2001; 276(13);10556-63 [Pubmed: 11152457]
Throughput
- Low Throughput
Additional Notes
- AGTR1 receptor-binding region located between amino acids 231 and 235 of Jak2
Curated By
- BioGRID