HSP90AA1
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- axon guidance [TAS]
- chaperone-mediated protein complex assembly [IDA]
- innate immune response [TAS]
- mitochondrial transport [TAS]
- mitotic cell cycle [TAS]
- nitric oxide metabolic process [TAS]
- positive regulation of nitric oxide biosynthetic process [ISS]
- protein import into mitochondrial outer membrane [IDA]
- protein refolding [TAS]
- regulation of nitric-oxide synthase activity [TAS]
- response to unfolded protein [NAS]
- signal transduction [NAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NLRP12
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [NAS]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of Toll signaling pathway [IDA]
- negative regulation of cytokine secretion [IDA]
- negative regulation of inflammatory response [IMP]
- negative regulation of interleukin-1 secretion [IDA]
- negative regulation of interleukin-6 biosynthetic process [IDA]
- negative regulation of protein autophosphorylation [IDA]
- negative regulation of signal transduction [IDA]
- positive regulation of MHC class I biosynthetic process [IDA]
- positive regulation of inflammatory response [NAS]
- positive regulation of interleukin-1 beta secretion [NAS]
- regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- regulation of interleukin-18 biosynthetic process [NAS]
- release of cytoplasmic sequestered NF-kappaB [IDA]
- signal transduction [NAS]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Heat shock protein 90 associates with monarch-1 and regulates its ability to promote degradation of NF-kappaB-inducing kinase.
Monarch-1/NLRP12 is expressed in myeloid cells and functions as a negative regulator of inflammation by inducing proteasome-mediated degradation of NF-kappaB-inducing kinase. Monarch-1 is a member of the CATERPILLER gene family, also known as the nucleotide-binding domain leucine-rich repeat gene family. This family shares strong structural homology to major immune regulators expressed in lower organisms, including plants. In plants, these disease-resistance ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID