BAIT

PPP1CC

PP-1G, PP1C, PPP1G
protein phosphatase 1, catalytic subunit, gamma isozyme
Alzheimer's Disease Project
Homo sapiens
PREY

STAU1

PPP1R150, STAU, RP3-470L14.2
staufen double-stranded RNA binding protein 1
Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Protein Phosphatase 1γ Isoforms Linked Interactions in the Brain.

Esteves SL, Korrodi-Gregorio L, Cotrim CZ, van Kleeff PJ, Domingues SC, da Cruz E Silva OA, Fardilha M, da Cruz E Silva EF

Posttranslational protein modifications, in particular reversible protein phosphorylation, are important regulatory mechanisms involved in cellular signaling transduction pathways. Thousands of human proteins are phosphorylatable and the tight regulation of phosphorylation states is crucial for cell maintenance and development. Protein phosphorylation occurs primarily on serine, threonine, and tyrosine residues, through the antagonistic actions of protein kinases and phosphatases. The catalytic subunit ... [more]

J. Mol. Neurosci. Oct. 19, 2012; 0(0); [Pubmed: 23080069]

Throughput

  • High Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
STAU1 PPP1CC
Proximity Label-MS
Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

High-BioGRID
3528160

Curated By

  • BioGRID