PINK1
Gene Ontology Biological Process
- TORC2 signaling [IC]
- activation of protein kinase B activity [IC]
- cellular response to hypoxia [IMP]
- cellular response to toxic substance [TAS]
- intracellular signal transduction [IDA]
- mitochondrion degradation [IMP]
- mitochondrion organization [IMP]
- negative regulation of JNK cascade [TAS]
- negative regulation of gene expression [ISS]
- negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway [IDA, IMP]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of oxidative stress-induced cell death [IDA]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IDA]
- negative regulation of oxidative stress-induced neuron death [TAS]
- negative regulation of reactive oxygen species metabolic process [IMP]
- peptidyl-serine autophosphorylation [TAS]
- peptidyl-serine phosphorylation [IDA, TAS]
- phosphorylation [NAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of mitochondrial electron transport, NADH to ubiquinone [TAS]
- positive regulation of mitochondrial fission [IBA]
- positive regulation of peptidase activity [TAS]
- positive regulation of peptidyl-serine phosphorylation [IDA, TAS]
- positive regulation of protein kinase B signaling [IC]
- positive regulation of release of cytochrome c from mitochondria [IMP]
- positive regulation of ubiquitin-protein transferase activity [TAS]
- protein phosphorylation [IDA, TAS]
- protein ubiquitination [IMP]
- regulation of mitochondrial membrane potential [IGI, IMP]
- regulation of mitochondrion degradation [TAS]
- regulation of protein complex assembly [IDA]
- regulation of protein ubiquitination [IDA]
- regulation of reactive oxygen species metabolic process [IGI, IMP]
- regulation of synaptic vesicle transport [TAS]
- response to oxidative stress [IGI]
- response to stress [IDA]
- ubiquitin-dependent protein catabolic process [TAS]
Gene Ontology Molecular Function- ATP binding [IDA]
- C3HC4-type RING finger domain binding [IPI]
- calcium-dependent protein kinase activity [IDA]
- kinase activity [IDA, NAS]
- magnesium ion binding [IDA]
- peptidase activator activity [TAS]
- protease binding [IPI, TAS]
- protein binding [IPI]
- protein kinase B binding [IDA]
- protein serine/threonine kinase activity [IDA, TAS]
- ubiquitin protein ligase binding [IPI]
- ATP binding [IDA]
- C3HC4-type RING finger domain binding [IPI]
- calcium-dependent protein kinase activity [IDA]
- kinase activity [IDA, NAS]
- magnesium ion binding [IDA]
- peptidase activator activity [TAS]
- protease binding [IPI, TAS]
- protein binding [IPI]
- protein kinase B binding [IDA]
- protein serine/threonine kinase activity [IDA, TAS]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
- Lewy body [TAS]
- TORC2 complex [IPI]
- astrocyte projection [IDA]
- axon [IDA]
- cell body [IDA]
- chromatin [IDA]
- cytoplasm [IDA]
- cytoskeleton [IDA]
- cytosol [IDA]
- integral component of mitochondrial outer membrane [IDA]
- membrane [IDA]
- mitochondrial inner membrane [IDA]
- mitochondrial intermembrane space [IDA]
- mitochondrial outer membrane [IDA]
- mitochondrion [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
TRAF6
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- I-kappaB kinase/NF-kappaB signaling [TAS]
- JNK cascade [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- T cell receptor signaling pathway [IMP, TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of MAPK activity [TAS]
- activation of NF-kappaB-inducing kinase activity [IMP]
- activation of protein kinase activity [IDA]
- apoptotic signaling pathway [TAS]
- cellular response to lipopolysaccharide [IDA]
- innate immune response [TAS]
- membrane protein intracellular domain proteolysis [TAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- nucleotide-binding oligomerization domain containing signaling pathway [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA, TAS]
- positive regulation of JUN kinase activity [IDA, NAS]
- positive regulation of NF-kappaB transcription factor activity [IDA, IMP, TAS]
- positive regulation of T cell activation [IC]
- positive regulation of T cell cytokine production [IMP]
- positive regulation of apoptotic process [TAS]
- positive regulation of interleukin-2 production [IMP]
- positive regulation of osteoclast differentiation [IDA]
- positive regulation of protein ubiquitination [NAS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, NAS]
- positive regulation of transcription regulatory region DNA binding [IDA]
- protein K63-linked ubiquitination [IDA, IGI]
- protein autoubiquitination [IDA, TAS]
- protein polyubiquitination [IDA]
- response to interleukin-1 [IDA]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function- histone deacetylase binding [IPI]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein kinase B binding [IPI]
- protein kinase binding [IPI]
- thioesterase binding [IPI]
- tumor necrosis factor receptor binding [IPI]
- ubiquitin conjugating enzyme binding [IDA]
- ubiquitin protein ligase binding [IPI]
- ubiquitin-protein transferase activity [EXP, IDA, TAS]
- histone deacetylase binding [IPI]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein kinase B binding [IPI]
- protein kinase binding [IPI]
- thioesterase binding [IPI]
- tumor necrosis factor receptor binding [IPI]
- ubiquitin conjugating enzyme binding [IDA]
- ubiquitin protein ligase binding [IPI]
- ubiquitin-protein transferase activity [EXP, IDA, TAS]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
PINK1 stimulates interleukin-1β-mediated inflammatory signaling via the positive regulation of TRAF6 and TAK1.
Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons in the substantia nigra. The cause of neuronal death in PD is largely unknown, but several genetic loci, including PTEN-induced putative kinase 1 (PINK1), have been linked to early onset autosomal recessive forms of familial PD. PINK1 encodes a serine/threonine kinase, which phosphorylates several substrates and consequently leads ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TRAF6 PINK1 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 882788 |
Curated By
- BioGRID