BAIT
IKBKAP
DYS, ELP1, FD, IKAP, IKI3, TOT1, RP11-3J11.4
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
GO Process (9)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- chromatin organization [TAS]
- immune response [TAS]
- positive regulation of cell migration [ISS]
- protein complex assembly [TAS]
- protein phosphorylation [TAS]
- regulation of protein kinase activity [IDA, TAS]
- regulation of transcription from RNA polymerase II promoter [IDA, TAS]
- signal transduction [TAS]
- transcription elongation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DYNC1H1
DHC1, DHC1a, DNCH1, DNCL, DNECL, DYHC, Dnchc1, HL-3, SMALED1, p22
dynein, cytoplasmic 1, heavy chain 1
GO Process (6)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration.
Loss-of-function mutations in the IKBKAP gene, which encodes IKAP (ELP1), cause familial dysautonomia (FD), with defective neuronal development and maintenance. Molecular mechanisms leading to FD are poorly understood. We demonstrate that various RNA-interference-based depletions of IKAP lead to defective adhesion and migration in several cell types, including rat primary neurons. The defects could be rescued by reintroduction of wild-type IKAP ... [more]
J. Cell. Sci. Mar. 15, 2008; 121(0);854-64 [Pubmed: 18303054]
Throughput
- Low Throughput
Curated By
- BioGRID