BAIT

LRP1

A2MR, APOER, APR, CD91, IGFBP3R, LRP, LRP1A, TGFBR5
low density lipoprotein receptor-related protein 1
Alzheimer's Disease Project
Cell Cycle - Mitotic Spindle Assembly Project
Homo sapiens
PREY

CHFR

RNF116, RNF196
checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
UPS Project
GO Process (3)
GO Function (3)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Publication

Aggregated Low-Density Lipoprotein Induces LRP1 Stabilization Through E3 Ubiquitin Ligase CHFR Downregulation in Human Vascular Smooth Muscle Cells.

Cal R, Garcia-Arguinzonis M, Revuelta-Lopez E, Castellano J, Padro T, Badimon L, Llorente-Cortes V

Low density lipoprotein retention and aggregation in the arterial intima are key processes in atherogenesis. Aggregated LDL (agLDL) is taken up through low-density lipoprotein receptor-related protein 1 (LRP1) by human vascular smooth muscle cells (VSMC). AgLDL increases LRP1 expression, at least in part, by downregulation of sterol regulatory element-binding proteins. It is unknown whether agLDL has some effect on the ... [more]

Arterioscler. Thromb. Vasc. Biol. Feb. 01, 2013; 33(2);369-77 [Pubmed: 23241409]

Throughput

  • Low Throughput

Curated By

  • BioGRID