DDIT3
Gene Ontology Biological Process
- activation of signaling protein activity involved in unfolded protein response [TAS]
- cell redox homeostasis [IDA]
- cellular protein metabolic process [TAS]
- cellular response to DNA damage stimulus [TAS]
- endoplasmic reticulum unfolded protein response [TAS]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IDA, IMP, TAS]
- mRNA transcription from RNA polymerase II promoter [IDA]
- negative regulation of canonical Wnt signaling pathway [ISS]
- negative regulation of determination of dorsal identity [IDA]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of interleukin-8 production [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [ISS]
- positive regulation of transcription, DNA-templated [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- regulation of DNA-templated transcription in response to stress [TAS]
- regulation of transcription involved in anterior/posterior axis specification [ISS]
- regulation of transcription, DNA-templated [IMP]
- response to endoplasmic reticulum stress [IDA]
- response to unfolded protein [IDA]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- protein heterodimerization activity [TAS]
- sequence-specific DNA binding transcription factor activity [NAS]
- transcription corepressor activity [TAS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [ISS]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- protein heterodimerization activity [TAS]
- sequence-specific DNA binding transcription factor activity [NAS]
- transcription corepressor activity [TAS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [ISS]
Gene Ontology Cellular Component
- CHOP-C/EBP complex [TAS]
- cytosol [TAS]
- nucleoplasm [IDA, TAS]
- nucleus [IDA, TAS]
CUL3
Gene Ontology Biological Process
- COPII vesicle coating [IMP]
- ER to Golgi vesicle-mediated transport [IDA]
- G1/S transition of mitotic cell cycle [TAS]
- cell cycle arrest [TAS]
- cell migration [IMP]
- embryonic cleavage [ISS]
- integrin-mediated signaling pathway [ISS]
- intrinsic apoptotic signaling pathway [TAS]
- mitotic metaphase plate congression [IMP]
- negative regulation of Rho protein signal transduction [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation [IDA]
- positive regulation of cell proliferation [TAS]
- positive regulation of cytokinesis [IMP]
- positive regulation of mitotic metaphase/anaphase transition [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein monoubiquitination [IDA]
- protein polyubiquitination [IDA]
- protein ubiquitination [IDA]
- stem cell division [ISS]
- stress fiber assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The COP9 signalosome, cullin 3 and Keap1 supercomplex regulates CHOP stability and adipogenesis.
Obesity is one of the most serious health problems of the 21(st) century. It is associated with highly increased risk of type 2 diabetes, high blood pressure, cardiovascular disease as well as several cancers. The expansion of the fat tissue needs the differentiation of preadipocytes to adipocytes, a process called adipogenesis. Dysfunction of adipogenesis is a hallmark of obesity and ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DDIT3 CUL3 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | Low | - | BioGRID | - |
Curated By
- BioGRID