PREY

NOTCH1

AOS5, AOVD1, TAN1, hN1
notch 1
GO Process (77)
GO Function (5)
GO Component (9)

Gene Ontology Biological Process

Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Non-degradative Ubiquitination of the Notch1 Receptor by the E3 Ligase MDM2 activates the Notch Signalling Pathway.

Pettersson S, Sczaniecka M, McLaren L, Russell F, Gladstone K, Hupp TR, Wallace M

The Notch receptor is necessary for modulating cell fate decisions throughout development and aberrant activation of Notch signalling has been associated with many diseases, including tumorigenesis. The E3 ligase MDM2 plays a role in regulating the Notch signalling pathway through its interaction with NUMB. Here we report that MDM2 can also exert its oncogenic effects on the Notch signalling pathway ... [more]

Biochem. J. Dec. 20, 2012; 0(0); [Pubmed: 23252402]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
NOTCH1 NUMB
Reconstituted Complex
Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Low-BioGRID
-

Curated By

  • BioGRID