KIN1
Gene Ontology Biological Process
Gene Ontology Cellular Component
PMP1
Gene Ontology Biological Process
- cellular chloride ion homeostasis [IMP]
- cellular response to salt stress [IMP]
- inactivation of MAPK activity [IDA]
- peptidyl-tyrosine dephosphorylation [IDA]
- peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [IDA]
- positive regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMP]
- protein dephosphorylation [IDA]
- regulation of cell morphogenesis [IMP]
- regulation of mitotic cytokinesis [IMP]
- regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMP]
Gene Ontology Molecular Function
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
The Kin1 kinase and the calcineurin phosphatase cooperate to link actin ring assembly and septum synthesis in fission yeast.
BACKGROUND INFORMATION: The Kin1 protein kinase of fission yeast, which regulates cell surface cohesiveness during interphase cell growth, is also present at the cell division site during mitosis; however, its function in cell division has remained elusive. RESULTS: In FK506-mediated calcineurin deficient cells, mitosis is extended and ring formation is transiently compromised but septation remains normal. Here we show that ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: septum formation (APO:0000221)
- phenotype: resistance to chemicals (APO:0000087)
Additional Notes
- double mutants show increased septation defects
- double mutants show increased septation defects in the presence of FK506 and 1NM-PP1
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KIN1 PMP1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -3.3757 | BioGRID | 774829 | |
| KIN1 PMP1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 448510 | |
| PMP1 KIN1 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 448502 | |
| KIN1 PMP1 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 816717 |
Curated By
- BioGRID