Protein-peptide

An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.

Publication

Examining posttranslational modification-mediated protein-protein interactions using a chemical proteomics approach.

Li X, Foley EA, Kawashima SA, Molloy KR, Li Y, Chait BT, Kapoor TM

Post-translational modifications (PTM) of proteins can control complex and dynamic cellular processes via regulating interactions between key proteins. To understand these regulatory mechanisms it is critical that we can profile the PTM-dependent protein-protein interactions. However, identifying these interactions can be very difficult using available approaches, as PTMs can be dynamic and often mediate relatively weak protein-protein interactions. We have recently ... [more]

Protein Sci. Dec. 27, 2012; 0(0); [Pubmed: 23281010]

Throughput

  • High Throughput|Low Throughput

Additional Notes

  • an H3T3-Phos peptide binds in vitro
  • products phto-crosslinked

Curated By

  • BioGRID